# Comparing the Effects of Age, Sex, and Extremity Fracture Location on Continuous Intra-compartmental Pressure (ICP) Measurements in Trauma Patients

**Authors:** Justin Matta, Yasser C Bouklouch, William Obremskey, Ross Leighton, Mitchell Bernstein, Edward J Harvey

PMC · DOI: 10.7759/cureus.99300 · Cureus · 2025-12-15

## TL;DR

This study examines how age, sex, and fracture location affect continuous intra-compartmental pressure measurements in trauma patients, revealing distinct trends that could improve diagnosis of acute compartment syndrome.

## Contribution

The study introduces new baseline data on intra-compartmental pressure trends using modern monitoring technology in non-ACS trauma patients.

## Key findings

- Younger patients had higher mean ICPs than older patients at all time points.
- Females showed a steeper decline in ICP over time compared to males.
- Tibia fractures were associated with higher initial pressure and steeper ICP declines than forearm fractures.

## Abstract

Background

Baseline data for extremity compartment pressure after trauma have only been looked at in small cohorts with historically inaccurate technology. Newer technology has enabled continuous, accurate pressure monitoring for the diagnosis of acute compartment syndrome (ACS). This study used data from prospective cohort trials with modern pressure sensors to examine baseline pressure values. Particularly, there was a comparison of the effects of age, sex, and fracture location on continuous trend behaviors in extremity trauma patients.

Methodology

Intracompartmental pressures (ICPs) from 129 non-ACS trauma patients with extremity fractures were examined. The trends in patients were analyzed with respect to age, sex, and anatomical fracture location.

Results

Younger patients exhibited higher mean ICPs compared to older patients at all time points. Both groups experienced the same rates of decline in pressure over time from trauma. Both older and younger patient groups experienced a steady linear decrease in pressure over the course of monitoring. The younger age group had a decrease of 0.202 mmHg per hour (y = 26.4 - 0.202x), and the older age group showed the same rate of decrease (y = 23.9 - 0.202x). Males and females initially had similar ICPs, but females showed a steeper decline over time, with the pressure in the female group decreasing at a mean rate of 0.303 mmHg/hour compared to 0.163 mmHg/hour in the male group. Tibia fractures were associated with a higher initial pressure and steeper declines in ICP compared to forearm fractures.

Conclusions

There are variances for continuous ICP measurements associated with age, sex, and fracture location in trauma patients who do not develop ACS. Continuous ICP monitoring offers a better understanding of pressure trends, allowing for more accurate and individualized assessments. Recognizing these trends is crucial in ACS assessment.

## Full-text entities

- **Diseases:** ACS (MESH:D000208), Fracture (MESH:D050723), Tibia fractures (MESH:C535563), Trauma (MESH:D014947), forearm fractures (MESH:D000092503), compartment syndrome (MESH:D003161)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12803435/full.md

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Source: https://tomesphere.com/paper/PMC12803435