# Blood substitution—More challenges for translational significance **Authors:** Xuefang Sophie Ren, Huimahn A. Choi, Aaron M. Gusdon, Heng Hu, Jude Savarraj, Atzhiry Paz, Ryan S. Kitagawa, James W. Simpkins PMC · DOI: 10.3389/fstro.2022.1050434 · Frontiers in Stroke · 2022-11-09 ## Full-text entities - **Genes:** PLP1 (proteolipid protein 1) [NCBI Gene 5354] {aka GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD}, CTSS (cathepsin S) [NCBI Gene 1520], HLA-C (major histocompatibility complex, class I, C) [NCBI Gene 3107] {aka D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1}, MBP (myelin basic protein) [NCBI Gene 4155], MOG (myelin oligodendrocyte glycoprotein) [NCBI Gene 4340] {aka BTN6, BTNL11, MOGIG2, NRCLP7}, CMAHP (cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene) [NCBI Gene 8418] {aka CMAH, CSAH}, B4GALNT2 (beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group)) [NCBI Gene 124872] {aka B4GALT, GALGT2}, GGTA1 (glycoprotein alpha-galactosyltransferase 1 (inactive)) [NCBI Gene 2681] {aka GGTA, GGTA1P, GLYT2, a1/3GTP}, Fgf21 (fibroblast growth factor 21) [NCBI Gene 56636] {aka Fgf8c} - **Diseases:** hemorrhagic stroke (MESH:D000083302), traumatic brain injury (MESH:D000070642), diabetes (MESH:D003920), inflammation (MESH:D007249), ischemia (MESH:D007511), Stroke (MESH:D020521), heart and blood vessel diseases (MESH:D009383), autoimmune disorders (MESH:D001327), neurological diseases (MESH:D020271), Infections (MESH:D007239), brain damage (MESH:D001925), middle cerebral artery occlusion (MESH:D020244), brain injury (MESH:D001930), arterial occlusions (MESH:D001157), blood dyscrasia (MESH:D006402), necrotic (MESH:D009336) - **Chemicals:** BR (-), ROS (MESH:D017382), lipids (MESH:D008055) - **Species:** Mus musculus (house mouse, species) [taxon 10090], Sus scrofa (pig, species) [taxon 9823], Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12802796/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12802796/full.md ## References 20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12802796/full.md --- Source: https://tomesphere.com/paper/PMC12802796