# Decoding ALS from the tail end of RNA

## TL;DR

This study explores how RNA processing at the 3′ end contributes to ALS/FTLD, revealing new insights into disease mechanisms and possible treatments.

## Contribution

The paper introduces a single-nucleus transcriptomic atlas showing widespread alternative polyadenylation changes in ALS/FTLD.

## Key findings

- Alternative polyadenylation changes are widespread in ALS/FTLD brain tissue.
- 3′ end RNA processing integrates stress responses and cell-type specificity in disease.
- Findings suggest new therapeutic directions for ALS/FTLD.

## Abstract

In this issue of Cell Genomics, McKeever et al.1 generate a single-nucleus transcriptomic atlas of ALS/FTLD brain and reveal widespread alternative polyadenylation changes. Their findings highlight 3′ end RNA processing as a central integrator of stress responses, cell-type specificity, and disease susceptibility, offering new mechanistic insight and potential therapeutic directions.

In this issue of Cell Genomics, McKeever et al. generate a single-nucleus transcriptomic atlas of ALS/FTLD brain and reveal widespread alternative polyadenylation changes. Their findings highlight 3′ end RNA processing as a central integrator of stress responses, cell-type specificity, and disease susceptibility, offering new mechanistic insight and potential therapeutic directions.