# RNA as a genome architect: G-loops in G-quadruplex regulation

**Authors:** Jie Wang, Zhao-Jie Lyu, Qi Zhang, William C. Cho, De-Chao Feng

PMC · DOI: 10.1186/s40779-025-00683-3 · Military Medical Research · 2026-01-14

## Full-text entities

- **Genes:** ATR (ATR checkpoint kinase) [NCBI Gene 545] {aka FCTCS, FRP1, MEC1, SCKL, SCKL1}, ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit) [NCBI Gene 2072] {aka ERCC11, FANCQ, RAD1, XFEPS, XPF}, RAD51 (RAD51 recombinase) [NCBI Gene 5888] {aka BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2}, DHX36 (DEAH-box helicase 36) [NCBI Gene 170506] {aka DDX36, G4R1, MLEL1, RHAU}, ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit) [NCBI Gene 2067] {aka COFS4, RAD10, UV20}, HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) [NCBI Gene 3178] {aka ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, MPD3}, ATM (ATM serine/threonine kinase) [NCBI Gene 472] {aka AT1, ATA, ATC, ATD, ATDC, ATE}, BRCA2 (BRCA2 DNA repair associated) [NCBI Gene 675] {aka BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD}, BRIP1 (BRCA1 interacting DNA helicase 1) [NCBI Gene 83990] {aka BACH1, FANCJ, OF}
- **Diseases:** cancer (MESH:D009369), neurodegeneration (MESH:D019636), frontotemporal dementia (MESH:D057180), Fanconi Anemia (MESH:D005199), ataxia-telangiectasia (MESH:D001260), amyotrophic lateral sclerosis (MESH:D000690)
- **Chemicals:** nucleotide (MESH:D009711), Li+ (MESH:D008094), guanine (MESH:D006147), Na+ (MESH:D012964), K+ (MESH:D011188)

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Source: https://tomesphere.com/paper/PMC12801905