# A black macule on the male nipple

**Authors:** Noriyoshi Fujii, Akemi Fukuda, Nozomi Kawahara, Keiko Kobayashi

PMC · DOI: 10.1016/j.jdcr.2025.11.015 · JAAD Case Reports · 2025-11-20

## Full-text entities

- **Genes:** EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, MLANA (melan-A) [NCBI Gene 2315] {aka MART-1, MART1}, ESR1 (estrogen receptor 1) [NCBI Gene 2099] {aka ER, ESR, ESRA, ESTRR, Era, NR3A1}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}
- **Diseases:** carcinoma (MESH:D009369), pigmentation (MESH:D010859), trauma (MESH:D014947), Nodular malignant melanoma (MESH:D008545), pain (MESH:D010146), fever (MESH:D005334), lymphadenopathy (MESH:D008206), bleeding (MESH:D006470), pigmented nipple lesions (MESH:C000626393), eccrine porocarcinoma (MESH:D057090), Pigmented mammary Paget disease (MESH:D010144), Male breast cancer (MESH:D018567), weight loss (MESH:D015431), epithelial neoplasm (MESH:D009375), basal cell carcinoma (MESH:D002280), Invasive ductal carcinoma (MESH:D044584), breast carcinoma (MESH:D001943)
- **Chemicals:** H&E (MESH:D006371), hematoxylin (MESH:D006416), eosin (MESH:D004801), melanin (MESH:D008543)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12800437/full.md

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Source: https://tomesphere.com/paper/PMC12800437