# Severe fetomaternal transfusion due to an unrecognized chorangioma in a dichorionic, diamniotic twin pregnancy

**Authors:** Jonas Bubmann, Christian Dannecker, Manuela Franitza, Marina Seefried, Philipp Voisard, Udo Jeschke, Carl Mathis Wild, Fabian Garrido, Tina Schaller, Bernadette Eser

PMC · DOI: 10.1007/s00404-025-08249-3 · Archives of Gynecology and Obstetrics · 2026-01-13

## TL;DR

A case report shows how a large chorangioma in a twin pregnancy caused severe fetomaternal transfusion, leading to fetal anemia and death.

## Contribution

Highlights the underrecognized risk of fetomaternal transfusion due to chorangiomas in twin pregnancies.

## Key findings

- A 6 cm chorangioma likely caused severe fetomaternal transfusion in a dichorionic twin pregnancy.
- Fetomaternal transfusion can lead to fetal anemia and perinatal death if undiagnosed.
- Early Doppler monitoring and awareness may improve outcomes in at-risk pregnancies.

## Abstract

Severe fetomaternal transfusion due to an unrecognized chorangioma in a dichorionic, diamniotic twin pregnancy: case report and review of the literature.

Case report and retrospective narrative review.

Evaluation of 8 case reports.

A 32-year-old primigravida with dichorionic, diamniotic twin pregnancy developed growth discordance and hypertension. At 35 weeks, cesarean delivery revealed one viable twin and one severely anemic twin who died immediately postnatal. Fetomaternal transfusion was suspected, confirmed, and most likely caused by a 6 cm chorangioma.

Fetomaternal hemorrhage is a serious but underrecognized complication and can be caused of placental chorioangiomas, among other things. Although rare, it poses significant risks of fetal anemia and perinatal morbidity. Increased awareness and routine Doppler monitoring of at-risk fetuses may facilitate earlier diagnosis and timely intervention, potentially improving outcomes. Particularly in children with anemia, fetomaternal transfusion should always be considered and HbF material determined.

## Linked entities

- **Diseases:** anemia (MONDO:0002280)

## Full-text entities

- **Diseases:** anemia (MESH:D000740), hypertension (MESH:D006973), growth discordance (MESH:D006130), Fetomaternal hemorrhage (MESH:D005331), chorangioma (MESH:D006391)

## Full text

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## Figures

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Source: https://tomesphere.com/paper/PMC12799650