# Infiltrative Endometriosis Clinically Mimicking Ovarian Malignancy: Diagnostic Utility of Intraoperative Frozen Section

**Authors:** Aparna Gupta, Reena Tomar, Robin Yadav, Deepika Rani, Asmita Rathore

PMC · DOI: 10.7759/cureus.99229 · Cureus · 2025-12-14

## TL;DR

This paper discusses a rare case where endometriosis mimicked ovarian cancer, highlighting the value of intraoperative frozen sections for accurate diagnosis.

## Contribution

The paper presents a novel case of infiltrative endometriosis clinically resembling ovarian malignancy and emphasizes the diagnostic utility of frozen sections.

## Key findings

- Infiltrative endometriosis can mimic ovarian malignancy with similar symptoms and elevated tumor markers.
- Intraoperative frozen section analysis proved critical in distinguishing endometriosis from cancer in this case.

## Abstract

Endometriosis is a benign gynecological condition that commonly affects women of reproductive age. It is characterized by the presence of ectopic endometrial tissue, predominantly within the pelvic cavity. Ovarian endometriosis usually presents as an endometrioma with typical clinical and radiological features. However, atypical presentations such as varied symptoms, elevated tumor markers, and inconclusive imaging often complicate the differentiation between benign and malignant ovarian masses. This poses significant diagnostic challenges, which can be addressed with the use of intraoperative frozen sections. We hereby report a case of infiltrative endometriosis that presented with clinical features, radiological findings, and elevated serum tumor markers suggestive of ovarian malignancy.

## Linked entities

- **Diseases:** endometriosis (MONDO:0005133)

## Full-text entities

- **Diseases:** Ovarian endometriosis (MESH:D010049), Endometriosis (MESH:D004715), Ovarian Malignancy (MESH:D010051), tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12799589/full.md

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Source: https://tomesphere.com/paper/PMC12799589