# Continuous Ketone Monitoring: Data From a Randomized Controlled Trial

**Authors:** Simon K Kjær, Lukas Ochsner Reynaud Ridder, Mads Svart, Nikolaj Rittig, Lise Nørkjær Bjerg, Birgitte Sandfeld-Paulsen, Henrik Holm Thomsen

PMC · DOI: 10.2196/85548 · JMIR Diabetes · 2026-01-13

## TL;DR

A continuous ketone monitoring device showed declining ketone levels over two weeks, possibly due to sensor drift.

## Contribution

The study evaluates a continuous ketone monitoring device's reliability during exogenous ketosis.

## Key findings

- BHB concentrations declined over 14 days in both ketone ester and placebo groups.
- Sensor drift is likely responsible for the observed decline in BHB measurements.

## Abstract

In our study, a commercially available continuous ketone monitoring device captured β-Hydroxybutyrate (BHB) dynamics during exogenous ketosis but revealed a gradual decline day-to-day BHB concentrations over 14 days in both ketone ester and placebo groups, likely reflecting sensor drift.

## Linked entities

- **Chemicals:** β-Hydroxybutyrate (PubChem CID 92135)

## Full-text entities

- **Genes:** CKM (creatine kinase, M-type) [NCBI Gene 1158] {aka CKMM, CPK-M, M-CK}
- **Diseases:** weight loss (MESH:D015431), ketosis (MESH:D007662), type 1 and type 2 diabetes (MESH:D003924), neurodegenerative, cardiovascular, and inflammatory conditions (MESH:D019636)
- **Chemicals:** NAD+ (MESH:D009243), ketone bodies (MESH:D007657), carbohydrate (MESH:D002241), KE (-), Ketone (MESH:D007659), BHB (MESH:D020155), osmium (MESH:D009992)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12799078/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12799078/full.md

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Source: https://tomesphere.com/paper/PMC12799078