# Methamphetamine use disorder, perceived impacts, and associated factors among adults receiving care at Sri Lanka’s National Institute of Mental Health: An analytical cross-sectional study

**Authors:** N. A. A. I. Nishshanka, T. N. L. Samarathunga, S. W. Inoka, R. Suharna, Dewarahandhi Kavishka Madushan De Silva, Kumarasinghe Arachchigey Sriyani, Nicholas Aderinto Oluwaseyi, Nicholas Aderinto Oluwaseyi, Nicholas Aderinto Oluwaseyi, Nicholas Aderinto Oluwaseyi, Nicholas Aderinto Oluwaseyi

PMC · DOI: 10.1371/journal.pone.0326469 · PLOS One · 2026-01-13

## TL;DR

This study examines methamphetamine addiction in Sri Lanka, finding it most affects young urban males and highlights the need for targeted interventions.

## Contribution

The study provides the first detailed analysis of methamphetamine use disorder in Sri Lanka, identifying key demographic and behavioral factors.

## Key findings

- Most users were young males from urban or semi-urban areas with moderate to severe addiction.
- Peer pressure and easy accessibility were major factors in initiating methamphetamine use.
- Common impacts included weight loss, irritability, and relationship problems.

## Abstract

Methamphetamine addiction poses a growing public health challenge in Sri Lanka, yet limited research explores its impacts on the addicted population. This study aimed to assess the severity, patterns, and perceived impacts of methamphetamine addiction among adult patients at the National Institute of Mental Health (NIMH), Angoda, Sri Lanka. An analytical cross-sectional study was conducted among adult clients (aged >18 years) diagnosed with methamphetamine use disorder according to DSM-5 criteria at NIMH, Sri Lanka. A sample of 427 participants was recruited through purposive sampling. Data were collected using a structured, self-developed, validated, interviewer-administered questionnaire covering sociodemographic details, addiction severity (DSM-5 criteria), consumption patterns, impacts, and reasons for use. Descriptive statistics were analyzed using SPSS version 26. All participants (100%) responded to the survey. Among participants, 93.7% were male, and 65.3% were aged 18–30 years. The majority resided in urban (57.9%) or semi-urban (36.1%) areas. Addiction severity was categorized as mild (29%), moderate (38.6%), and severe (32.3%). Most (65.3%) initiated methamphetamine use between 21–30 years. Smoking (52.7%) and snorting (44.9%) were common methods of use, with peer pressure (48.9%) cited as the primary reason for initiation. The most cited physical impacts were weight loss (38.8%) and loss of appetite (37.2%), while irritability (28.8%) and interpersonal relationship problems (50.8%) were cited as common mental and social perceived impacts, respectively. Findings reveal that young urban males are predominantly affected by methamphetamine addiction, with moderate to severe dependence common. methamphetamine addiction severity was associated with living arrangement, monthly income, living area, age of onset, frequency of consumption, method of consumption, and accessibility (p < 0.05). Peer influence and easy accessibility were significant contributing factors. The physical, mental, and social health impacts emphasize the urgent need for comprehensive intervention strategies focusing on prevention, early detection, and integrated rehabilitation services at the national level.

## Linked entities

- **Chemicals:** methamphetamine (PubChem CID 1206)

## Full-text entities

- **Genes:** CES2 (carboxylesterase 2) [NCBI Gene 8824] {aka CE-2, CES2A1, PCE-2, iCE}
- **Diseases:** Irritability (MESH:D001523), physical and sexual abuse (MESH:D000082002), mental health disorders (OMIM:603663), delusions (MESH:D063726), loss of appetite (MESH:D001068), post-traumatic stress disorder (MESH:D013313), aggression (MESH:D010554), myalgia (MESH:D063806), dysphoria (MESH:D019052), social dysfunction (MESH:D000067404), skin infections (MESH:D007239), drug (MESH:D000081015), panic attacks (MESH:D016584), Muscle rigidity (MESH:D009127), Withdrawal symptoms (MESH:D013375), DSM-5 (MESH:D008232), Methamphetamine use disorder (MESH:D000437), Dental problems (MESH:D019973), MA addiction (OMIM:157300), arrests (MESH:D006323), toxicity (MESH:D064420), dry mouth (MESH:D014987), Loss (MESH:D016388), Methamphetamine addiction (MESH:D019966), muscle cramps (MESH:D009120), major depression (MESH:D003865), hallucinations (MESH:D006212), fatigue (MESH:D005221), neurotoxic (MESH:D020258), Weight loss (MESH:D015431), chest pain (MESH:D002637), antisocial personality (MESH:D000987), Sleep problems (MESH:D012893), Cognitive impairments (MESH:D003072), cardiovascular collapse (MESH:D002318), agitation (MESH:D011595), malnourishment (MESH:D044342), cough (MESH:D003371), trauma (MESH:D014947), obsessive-compulsive disorder (MESH:D009771), depression (MESH:D003866), sweating (MESH:D013543), headaches (MESH:D006261), hair loss (MESH:D000505), psychosis (MESH:D011618), Compulsive behaviors (MESH:D003193), impaired judgment (MESH:D060825), SCID (MESH:D053632), insomnia (MESH:D007319), anorexia (MESH:D000855), jaw clenching (MESH:D007571), Anxiety (MESH:D001007), meth mouth (MESH:D009059), distress (MESH:D012128), suicidal ideation (MESH:D001072)
- **Chemicals:** Methamphetamine (MESH:D008694), Methamphetamine addiction (-), amphetamine (MESH:D000661), heroin (MESH:D003932), alcohol (MESH:D000438), amphetamines (MESH:D000662)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12798982/full.md

## References

56 references — full list in the complete paper: https://tomesphere.com/paper/PMC12798982/full.md

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Source: https://tomesphere.com/paper/PMC12798982