# Copper Nanocluster‐Decorated Magnesium Silicate‐Based Microneedle Enhances Antimicrobial Effects and Tissue Remodeling for Diabetic Wounds

## TL;DR

A new microneedle system using copper nanoclusters and magnesium silicate nanoparticles helps heal diabetic wounds by fighting bacteria and improving tissue repair.

## Contribution

A novel microneedle system combining copper nanoclusters and magnesium silicate nanoparticles for synergistic diabetic wound healing is developed.

## Key findings

- The system achieves a sterilization rate of >99.9% against bacteria.
- It regulates wound microenvironment by reducing hypoxia and ROS while promoting angiogenesis.
- In vivo studies show accelerated wound closure and improved tissue regeneration in diabetic models.

## Abstract

Diabetic skin lesions, as one of the most common complications of diabetes, present chronic nonhealing wounds that face dual challenges of antibiotic‐resistant bacteria threat and insufficient microenvironment regulation due to hyperglycemic conditions, bacterial infections, and multiple pathological factors (e.g., hypoxia and reactive oxygen species (ROS) accumulation and growth factor deficiency). This study develops a microneedle (MN) system integrated with copper nanocluster‐decorated magnesium silicate nanoparticles (denoted as MS@Cu MNs), which enables efficient diabetic wound healing via a synergistic multimechanism strategy. Leveraging the unique enzyme‐mimetic activity of copper nanoclusters (CuNCs) and the angiogenic properties of magnesium silicate nanoparticles (MS NPs), the engineered MS@Cu nanocomposites demonstrate: 1) broad‐spectrum antibacterial efficacy (sterilization rate >99.9%), 2) microenvironment regulation via simultaneous hypoxia mitigation, ROS scavenging, and angiogenesis promotion, and 3) enhanced fibroblast proliferation and migration through PI3K‐AKT signaling pathway activation. The MN system using γ‐polyglutamic acid (γPGA) as a matrix exhibits both superior mechanical strength and excellent biodegradability. In vivo studies demonstrated accelerated closure of infected diabetic wounds in animal models, with histological analysis revealing robust mature collagen deposition and tissue regeneration. This study develops an integrated strategy for chronic diabetic wound management, combining potentiated antibacterial activity with targeted microenvironment remodeling.

A microneedle dressing incorporating copper nanocluster‐decorated magnesium silicate nanoparticles has been fabricated for treating infected diabetic wounds through initial antibacterial effects, subsequent microenvironment regulation via simultaneous hypoxia mitigation, reactive oxygen species scavenging, and angiogenesis promotion, and fibroblast proliferation and migration promotion through PI3K‐AKT signaling pathway activation.© 2026 WILEY‐VCH GmbH