# Glycaemic control and complications in haemodialysis patients: the TURK-HEMODIAB Study

## TL;DR

This study examines glycaemic control and complications in diabetic haemodialysis patients in Turkey, finding higher HbA1c levels are linked to worse health outcomes.

## Contribution

The study provides a large-scale analysis of glycaemic control and its complications in diabetic haemodialysis patients in Turkey.

## Key findings

- Higher HbA1c levels correlate with increased blood pressure and higher rates of complications like coronary artery disease and diabetic retinopathy.
- Poor glycaemic control is associated with higher rates of diabetic foot disease and amputation.
- Age decreases and BMI increases the risk of higher HbA1c levels in diabetic haemodialysis patients.

## Abstract

The most common cause of end-stage kidney disease is diabetes mellitus (DM). The most commonly used renal replacement therapy in Turkey and in many countries around the world is haemodialysis (HD). Glycaemia control is important in these populations. In this study we aimed to screen for glycaemic control and complications in a large population of diabetic HD patients in Turkey.

A total of 16 043 patients were screened in 253 dialysis centres in Turkey and 5038 diabetic HD patients were included in the study. At participating centres, patients’ diabetes history, complications, medications, haemoglobin A1c (HbA1c) and other laboratory data were reviewed and recorded by nephrologists.

The average age of the patients was 64.0 ± 11.2 years and 56% were male. The mean HbA1c was 7.4 ± 1.5%. Patients were divided into three groups according to the HbA1c level (<6.5%, 6.5–8% and >8%). As the HbA1c levels increased, the mean systolic blood pressure and diastolic blood pressure increased significantly. In addition, as the HbA1c levels increased, the number of patients with coronary artery disease, patients undergoing coronary artery bypass graft surgery and the rate of patients with diabetic retinopathy and vision loss increased. Diabetic foot disease and amputation rates were also higher in the group with poor glycaemic control. The number of patients using intensive or mixed insulin was also higher in the group with high HbA1c levels. In ordinal logistic regression analysis, age significantly decreased and higher body mass index slightly increased the risk of a higher HbA1c. Also, the need for a diabetic diet was greater in those with high HbA1c levels.

Our study highlights that the target values for diabetic HD patients in Turkey are partially compatible with the 2022 Kidney Disease: Improving Global Outcomes guidelines for diabetes management. Nevertheless, more effort and teamwork are needed to improve patient outcomes.