# Transitioning to Shorter, Oral Antimicrobial Therapy for Pelvic Osteomyelitis in Patients Living With Spinal Cord Injury

**Authors:** Dhineli Perera, Ben Clegg, Ash Thomas, Sara Vogrin, Satwik Motaganahalli, Richard Clements, Caroline McFarlane, Estelle Petch, Andrew Nunn, Jason A Trubiano, Gemma K Reynolds

PMC · DOI: 10.1093/ofid/ofaf805 · 2026-01-06

## TL;DR

A study found that shorter oral antibiotic treatments can effectively treat pelvic osteomyelitis in spinal cord injury patients.

## Contribution

The study demonstrates the effectiveness of shorter, quinolone-sparing oral antimicrobial regimens in treating pelvic osteomyelitis.

## Key findings

- 4- to 6-week oral antimicrobial regimens achieved high clinical cure rates.
- Multidisciplinary care supported effective treatment outcomes.
- Findings support antibiotic stewardship and inform future treatment guidelines.

## Abstract

An 8-year prospective cohort study of pelvic osteomyelitis in patients living with spinal cord injury shows that 4- to 6-week, post-debridement, quinolone-sparing oral antimicrobial regimens were effective within multidisciplinary care. Clinical cure (89% at 12 months) remained high with shorter durations. These real-world findings support stewardship and inform prescribing and future trials.

## Linked entities

- **Chemicals:** quinolone (PubChem CID 6038)
- **Diseases:** spinal cord injury (MONDO:0043797)

## Full-text entities

- **Diseases:** Spinal Cord Injury (MESH:D013119), Pelvic Osteomyelitis (MESH:D010019)
- **Chemicals:** quinolone (MESH:D015363)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12798714/full.md

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Source: https://tomesphere.com/paper/PMC12798714