# Complete genome sequence of strain JHJ, a chloromethane-degrading anaerobe affiliated with the family Oscillospiraceae

**Authors:** Huijuan Jin, Yi Yang, Ke Shi, Xiuying Li, Jingjing Wang, Yiru Cui, Siqi Huang, Tongyue Zhou, Guanchi Liu, Gao Chen, Frank E. Löffler, Jun Yan

PMC · DOI: 10.1128/mra.00983-25 · 2025-11-24

## TL;DR

This paper presents the genome sequence of a bacteria strain that can break down chloromethane into formate and acetate.

## Contribution

The study provides the complete genome sequence of a novel chloromethane-degrading anaerobic bacterium.

## Key findings

- Strain JHJ has a 2.2 Mbp circular chromosome with 52.5% G + C content.
- The genome encodes an incomplete Wood-Ljungdahl pathway and 52 putative methyltransferases.

## Abstract

Oscillospiraceae bacterium strain JHJ, an anerobe isolated from estuarine sediment, degrades chloromethane to formate and acetate. The genome of strain JHJ consists of a 2.2 Mbp circular chromosome with a G + C content of 52.5% and encodes an incomplete Wood-Ljungdahl pathway and 52 putative methyltransferases.

## Linked entities

- **Chemicals:** chloromethane (PubChem CID 6327), formate (PubChem CID 283), acetate (PubChem CID 175)
- **Species:** Oscillospiraceae (taxon 216572)

## Full-text entities

- **Chemicals:** formate (MESH:C030544), acetate (MESH:D000085), chloromethane (MESH:D008737)

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Source: https://tomesphere.com/paper/PMC12798067