# Multiple sclerosis severity variant in DYSF-ZNF638 locus associates with neuronal loss and inflammation

**Authors:** Hendrik J. Engelenburg, Aletta M.R. van den Bosch, J.Q. Alida Chen, Cheng-Chih Hsiao, Marie-José Melief, Adil Harroud, Inge Huitinga, Jörg Hamann, Joost Smolders

PMC · DOI: 10.1016/j.isci.2025.114529 · 2025-12-26

## Full-text entities

- **Genes:** ZNF638 (zinc finger protein 638) [NCBI Gene 27332] {aka NP220, ZFML, Zfp638}, DYSF (dysferlin) [NCBI Gene 8291] {aka FER1L1, LGMD2B, LGMDR2, MMD1}
- **Diseases:** neuronal loss (MESH:D009410), inflammation (MESH:D007249), Multiple sclerosis (MESH:D009103)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12797034/full.md

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Source: https://tomesphere.com/paper/PMC12797034