# A modular “Catch-and-Play” platform for rapid T-cell engager target assembly for personalised cancer treatment

**Authors:** Xi Xi, Yonghui Zhang, Daqing Zhao, Fangfang Chen, Kenneth A. Howard

PMC · DOI: 10.1038/s41392-025-02557-5 · Signal Transduction and Targeted Therapy · 2026-01-12

## Full-text entities

- **Genes:** SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, GPT (glutamic--pyruvic transaminase) [NCBI Gene 2875] {aka AAT1, ALT, ALT1, GPT1, SGPT}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, FCGRT (Fc gamma receptor and transporter) [NCBI Gene 2217] {aka FCRN, FcgammaRn, alpha-chain}
- **Diseases:** breast cancer (MESH:D001943), cytotoxicity (MESH:D064420), Tumour (MESH:D009369)
- **Chemicals:** urea (MESH:D014508), T (MESH:D014316), E (MESH:D004540), Cetuximab (MESH:D000068818), Nb (MESH:D009556), PBS (MESH:D007854), OKT3 (MESH:D016853), Ni (MESH:D009532), CFSE (MESH:C087165), Albu-Catch-T (-)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** HMEC-1 — Homo sapiens (Human), Transformed cell line (CVCL_0307), Albu-Catch-T — Homo sapiens (Human), Esophageal squamous cell carcinoma, Cancer cell line (CVCL_3174), MDA-MB-231 — Homo sapiens (Human), Breast adenocarcinoma, Cancer cell line (CVCL_0062), Nb 7D12 — Homo sapiens (Human), Childhood T acute lymphoblastic leukemia, Cancer cell line (CVCL_W647), HEK293E — Homo sapiens (Human), Transformed cell line (CVCL_6974)

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Source: https://tomesphere.com/paper/PMC12796408