# Propensity-matched multicenter comparison of Parkinson’s disease outcomes with and without deep brain stimulation

## TL;DR

This study compares Parkinson's disease outcomes with and without deep brain stimulation using real-world data, showing improved mid-term quality of life for patients receiving the treatment.

## Contribution

The study demonstrates the feasibility of using propensity-matched observational data to evaluate deep brain stimulation outcomes in real-world settings.

## Key findings

- Deep brain stimulation was associated with improved mid-term motor and non-motor daily living experiences.
- The study used propensity-matched comparisons in an open observational cohort.
- Long-term effects of the intervention remain under investigation.

## Abstract

Subthalamic deep brain stimulation is established for Parkinson’s disease, reducing funding for randomized trials and necessitating complementary approaches to assess outcomes in broader clinical contexts. Using publicly available multicenter data, we compared propensity-matched patients with and without stimulation. The intervention was associated with improved mid-term patient-reported motor and non-motor experiences of daily living, while ongoing follow-up will clarify long-term effects. This demonstrates feasibility of matched comparisons in open observational cohorts.