# NFκB/IL-6/JAK2/STAT axis in myelofibrosis is a key vulnerability that is targetable and relevant to JAK2 inhibitor treatment resistance

**Authors:** Huiqin Bian, Naseema Gangat, Na Shen, Jiuxia Pang, David Wald, William Tse, Ayalew Tefferi, Fei Yan, Shujun Liu

PMC · DOI: 10.1038/s41408-025-01447-x · Blood Cancer Journal · 2026-01-12

## Full-text entities

- **Genes:** Cxcl15 (C-X-C motif chemokine ligand 15) [NCBI Gene 20309] {aka Il8, Scyb15, lungkine, weche}, MCL1 (MCL1 apoptosis regulator, BCL2 family member) [NCBI Gene 4170] {aka BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1}, JAK2 (Janus kinase 2) [NCBI Gene 3717] {aka JTK10}, CXCL8 (C-X-C motif chemokine ligand 8) [NCBI Gene 3576] {aka GCP-1, GCP1, IL8, LECT, LUCT, LYNAP}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, Jak2 (Janus kinase 2) [NCBI Gene 16452] {aka Fd17}, Stat5a (signal transducer and activator of transcription 5A) [NCBI Gene 20850] {aka STAT5}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, IL6R (interleukin 6 receptor) [NCBI Gene 3570] {aka CD126, HIES5, IL-1Ra, IL-6R, IL-6R-1, IL-6RA}, Casp3 (caspase 3) [NCBI Gene 12367] {aka A830040C14Rik, AC-3, CASP-3, CC3, CPP-32, CPP32}, STAT5A (signal transducer and activator of transcription 5A) [NCBI Gene 6776] {aka MGF, STAT5}, Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105) [NCBI Gene 18033] {aka NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105}, CASP8 (caspase 8) [NCBI Gene 841] {aka ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5}, Stat3 (signal transducer and activator of transcription 3) [NCBI Gene 20848] {aka 1110034C02Rik, Aprf}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, Il6 (interleukin 6) [NCBI Gene 16193] {aka Il-6}, Il6ra (interleukin 6 receptor, alpha) [NCBI Gene 16194] {aka CD126, IL-6R, IL-6R-alpha, IL-6RA, Il6r}, CASP3 (caspase 3) [NCBI Gene 836] {aka CPP32, CPP32B, SCA-1}, Mki67 (antigen identified by monoclonal antibody Ki 67) [NCBI Gene 17345] {aka D630048A14Rik, Ki-67, Ki67}, STAT3 (signal transducer and activator of transcription 3) [NCBI Gene 6774] {aka ADMIO, ADMIO1, APRF, HIES}
- **Diseases:** ineffective erythropoiesis (MESH:C563479), HD (MESH:D000067329), inflammation (MESH:D007249), MF (MESH:D055728), hypersensitivity (MESH:D004342), ET (MESH:D016751), MPN (MESH:D009369), leukemic (MESH:D007938), splenomegaly (MESH:D013163), PV (MESH:D011087)
- **Chemicals:** ruxolitinib (MESH:C540383), Ixazomib (MESH:C548400), eosin (MESH:D004801), BMS (MESH:C095300), H&E (MESH:D006371), Emetine (MESH:D004640), H&E Hematoxylin (-), BMS-911543 (MESH:C571029)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Mutations:** JAK2 V617F
- **Cell lines:** HEL — Homo sapiens (Human), Erythroleukemia, Cancer cell line (CVCL_0001)

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Source: https://tomesphere.com/paper/PMC12795839