# A 2nd-generation scalable synthesis of the HIV-1 entry inhibitor CJF-III-288 enabled by photoredox catalysis

## TL;DR

Scientists improved the production process for an HIV-1 drug, making it more efficient and scalable.

## Contribution

A new, more efficient synthesis method for CJF-III-288 using photoredox catalysis is introduced.

## Key findings

- The new synthesis eliminates the use of noble metals.
- The process reduces the number of steps and increases the overall yield tenfold.

## Abstract

The development and optimization of a 2nd-Generation process synthesis for the human immunodeficiency virus-1 entry inhibitor CJF-III-288 bis-trifloroacetate salt 1 is reported. The route eliminates the use of noble metals, decreases the step count nearly by half, and increases the overall yield tenfold.

The development of a 2nd-generation synthesis for the human immunodeficiency virus-1 entry inhibitor CJF-III-288 bis-trifloroacetate salt 1 is reported.