# Amplitude-Integrated/Continuous Electroencephalography for Early Detection of Low Cardiac Output After Chest Closure in an Infant

**Authors:** Alessandro Barbaria, Mariarita Capizzi, Federica Sperandeo, Gloria Castelli, Giuseppe Isgrò, Tommaso Aloisio, Angela Satriano, Alessandro Giamberti, Massimo Mastrangelo, Marco Ranucci

PMC · DOI: 10.1016/j.jaccas.2025.105363 · JACC Case Reports · 2025-09-17

## TL;DR

Amplitude-integrated/continuous EEG can detect early signs of low cardiac output in infants, even when other monitoring appears normal.

## Contribution

This case demonstrates aEEG/cEEG's potential to identify cerebral compromise from LCOS earlier than conventional methods.

## Key findings

- aEEG/cEEG showed early EEG abnormalities before clinical signs of LCOS recurrence.
- Cerebral distress was resolved after chest reopening, confirming aEEG/cEEG's predictive value.
- Standard monitoring failed to detect LCOS despite aEEG/cEEG showing early signs.

## Abstract

Weaning from cardiopulmonary bypass in pediatric cardiac surgery is challenging, especially after prolonged procedures. Delayed chest closure may be necessary in cases of low cardiac output syndrome (LCOS) to support hemodynamic recovery. Although near-infrared spectroscopy is standard for neuromonitoring, amplitude-integrated electroencephalography (aEEG) and continuous electroencephalography (cEEG) are emerging tools.

We report the case of a 6-month-old infant with transposition of the great arteries who required delayed chest closure after surgical repair. LCOS recurred after chest closure on postoperative day 3 despite stable near-infrared spectroscopy values. Retrospective aEEG/cEEG analysis, unintentionally initiated before closure, showed early EEG abnormalities preceding clinical signs, which were resolved after chest reopening.

This case highlights the potential of aEEG/cEEG to detect early cerebral compromise due to LCOS, even when conventional monitoring appears normal, an association not well established in the literature.

Cerebral distress may be detected earlier with aEEG compared with standard monitoring, supporting timely LCOS identification and management.

## Linked entities

- **Diseases:** transposition of the great arteries (MONDO:0000153)

## Full-text entities

- **Diseases:** transposition of the great arteries (MESH:D014188), Cerebral distress (MESH:D012128), LCOS (MESH:D002303), cerebral compromise (MESH:D002547)

## Full text

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12793864/full.md

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Source: https://tomesphere.com/paper/PMC12793864