# Beyond Otitis Media: When Mastoiditis Leads to Life‐Threatening Complications in Children

**Authors:** Ema Dejhalla, Ema Ahel Ledić, Petar Žauhar

PMC · DOI: 10.1155/crpe/6697317 · Case Reports in Pediatrics · 2026-01-12

## TL;DR

A child with severe mastoiditis developed life-threatening brain complications, highlighting the need for early imaging and prompt treatment.

## Contribution

This case emphasizes the importance of timely multidisciplinary care in managing severe mastoiditis in children.

## Key findings

- A 4-year-old girl with mastoiditis developed cerebral venous sinus thrombosis and intracranial complications.
- Early imaging and treatment with ceftriaxone and anticoagulation improved the patient's outcome.
- Mastoidectomy and tympanostomy tube placement were effective in resolving the infection.

## Abstract

Acute mastoiditis, a complication of acute otitis media (AOM), remains a concern in children despite vaccines and antibiotics. Serious complications like cerebral venous sinus thrombosis (CVST) can be life‐threatening.

A 4‐year‐old girl with fever, vomiting, and ear pain worsened despite amoxicillin treatment, developing headache, neck stiffness, and drowsiness. An ENT examination showed thickened tympanic membranes. Neurological symptoms, including headache, drowsiness, and neck stiffness, prompted lumbar puncture and initiation of ceftriaxone, with elevated CRP and leukocytosis supporting the clinical suspicion. Imaging confirmed otomastoiditis with epidural extension and CVST. MRI confirmed intracranial complications, prompting anticoagulation. She underwent mastoidectomy and tympanostomy tube placement, recovering well.

Early imaging and multidisciplinary management are essential to prevent neurologic complications in children with mastoiditis.

## Linked entities

- **Chemicals:** amoxicillin (PubChem CID 33613), ceftriaxone (PubChem CID 5479530)
- **Diseases:** acute otitis media (MONDO:0024330), mastoiditis (MONDO:0000748)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** AOM (MESH:D010033), neck stiffness (MESH:D006258), Mastoiditis (MESH:D008417), leukocytosis (MESH:D007964), vomiting (MESH:D014839), ear pain (MESH:D010031), fever (MESH:D005334), CVST (MESH:D012851), neurologic complications (MESH:D002493), headache (MESH:D006261), Complications (MESH:D008107)
- **Chemicals:** ceftriaxone (MESH:D002443), amoxicillin (MESH:D000658)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12793773/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12793773/full.md

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Source: https://tomesphere.com/paper/PMC12793773