# P-139. Prophylactic Antibiotics for Transcatheter Aortic Valve Implantation (TAVI) at a UK Cardiothoracic Centre

## TL;DR

This study found that most patients undergoing TAVI at a UK hospital did not receive recommended antibiotics to prevent a rare but serious infection, prompting new guidelines.

## Contribution

The paper introduces a revised prophylactic antibiotic regimen for TAVI aligned with updated ESC guidelines and highlights the need for a dedicated endocarditis database.

## Key findings

- 88% of patients received cefuroxime, which lacks Enterococcus coverage, while only 12% received Teicoplanin.
- Three cases of TAVI-related endocarditis were identified, including one caused by Enterococcus faecalis.
- A new institutional guideline was developed to ensure appropriate prophylaxis for future TAVI procedures.

## Abstract

TAVI is an increasingly used alternative to surgical aortic valve replacement. Infective endocarditis post TAVI, while uncommon, is a serious complication, with Enterococcus spp. frquently implicated. In 2023, the European Society of Cardiology(ESC) issued updated Endocarditis guidelines recommending prophylaxis with activity against Enterococcus spp. prior to TAVI(Delgado teal., Eur Heart J, 2023). Local guidance at our institution had not previously addressed this.Figure 1:Antibioitic prescriptions for TAVI

Antibioitic prescriptions for TAVI

A retrospective review of electronic antibiotic prescriptions for TAVI was performed at James Cook University Hospital between April and November 2023. Cases of TAVI-related Endocarditis from January 2022 to January 2024 were identified via IE MDT records and ICD-coded hospital data. Findings were reviewed with microbiology, infectious diseases, and cardiology services.

Among 115 prescriptions for 112 patients, 101(88%) received cefuroxime 1.5g IV monotherapy, and 14(12%) received Teicoplanin 400mg IV monotherapy. Only Teicoplanin provided Enterococcus coverage. No patient received prophylaxis aliged with ESC or local guidance. Three cases of TAVI-related IE were identified: Enterococcus faecalis, Streptococcus oxalis, and Streptococcus gordonii. These findings informed he development of a revised prophylactic regimen incorporating specific coverage for Enterococcus spp., agreed upon through multidisciplinary collaboration.

At our centre, the most patients undergoing TAVI did not receive prophylaxis with appropriate Enterococcus spp coverage, falling short of current ESC guideline recommendations. These findings prompted the development and implementation of a new institutional guideline, which will be monitered through prospective study. Addtionally, there is a pressing need for a dedicated TAVI endocarditis database to inform national and international prophylaxis strategies based on robust epidemiological data.

All Authors: No reported disclosures