P-1727. Defining Uncomplicated Candidemia suitable for “shorter is better” Treatment
Ilana Reinhold, Susanne Picardi, Blasius Liss, Danila Seidel, Jannik Stemler, Philipp Koehler, Tamara Rügamer, Rosanne Sprute, Oliver A Cornely
TL;DR
This paper proposes criteria to distinguish uncomplicated from complicated candidemia to guide shorter treatment durations for selected patients.
Contribution
The paper introduces a systematic definition for uncomplicated candidemia based on host factors, treatment response, and microbiological outcomes.
Findings
Uncomplicated candidemia is defined by blood culture clearance within five days and clinical/mycological response within 120 hours.
Patients with immunosuppression or echinocandin-resistant Candida species are classified as complicated.
Time-dependent criteria help differentiate uncomplicated from complicated cases.
Abstract
The success of candidemia treatment depends on patient baseline characteristics, as well as clinical and microbiological findings. While few patient populations with candidaemia are considered at risk for complications, such as neutropenic patients, further stratification criteria distinguishing uncomplicated from complicated disease remain undefined. This literature review aimed to propose criteria for defining uncomplicated candidemia.Figure 1Criteria differentiating uncomplicated and complicated candidaemia.Figure 2Time-dependent criteria for distinguishing uncomplicated from complicated candidemia. Criteria differentiating uncomplicated and complicated candidaemia. Time-dependent criteria for distinguishing uncomplicated from complicated candidemia. A systematic review was performed including literature from 1999 to 2025 to analyse outcome data of different studies and identify…
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Taxonomy
TopicsNeutropenia and Cancer Infections · Antifungal resistance and susceptibility · Blood disorders and treatments