P-368. Population Pharmacokinetic Analysis of Islatravir and the Impact of Intrinsic Factors in Participants with HIV-1

TL;DR

Researchers studied how islatravir, an HIV drug, behaves in the body and found that a lower dose may still be effective for most patients.

Contribution

A population pharmacokinetic model was developed to determine optimal dosing of islatravir for HIV treatment.

Findings

A 5-compartment model best described islatravir and its active form in the body.

Age, weight, and kidney function affected drug levels but not clinically significant efficacy.

A reduced dose of islatravir maintains effectiveness against HIV strains.

Abstract

Islatravir (ISL) is an investigational nucleoside reverse transcriptase translocation inhibitor being evaluated in combination regimens for the treatment of HIV-1. A population pharmacokinetic (PopPK) model was constructed to describe the pharmacokinetics (PK) of plasma ISL and its intracellular active anabolite ISL-triphosphate (ISL-TP). This work was aimed to provide dosing recommendations for ISL for the treatment of HIV-1 and identify the ISL-TP exposure associated with activity against wild-type virus and M184I/V variants.

Plasma and peripheral blood mononuclear cell (PBMC) samples were analyzed from adult and pediatric participants with and without HIV-1 receiving ISL across 18 studies, including two Phase 3 studies being conducted to evaluate oral ISL 0.25 mg once daily (QD) in combination with doravirine 100 mg. A PopPK model was developed and used to 1) evaluate the clinical relevance of intrinsic factors for ISL PK (ie, age, weight, sex at birth, race/ethnicity, mild/moderate renal impairment) and 2) determine the lower clinical bound based on inhibitory quotient (IQ) targets (defined as the trough ISL-TP concentration / 5 × the in vitro ISL ISL-TP EC50).

The analysis included 16,230 plasma ISL and 3999 PBMC ISL-TP concentrations from 2321 adult participants. Plasma ISL and PBMC ISL-TP were best characterized using a 5-compartment model with linear absorption and elimination. Age, weight, estimated glomerular filtration rate and disease status (without/with HIV) were statistically significant covariates on the PK of ISL; however, none of these intrinsic factors correlated with clinically significant changes in ISL exposure (Figure 1). Final model-based simulations showed that ISL 0.15 mg QD (corresponding to a 0.6-fold reduction in ISL AUC0-24, compared with ISL 0.25 mg) results in an ISL-TP C24 that meets IQ targets for wild-type virus and M184I/V variants (Figure 2).

The PopPK model captured the PK of ISL and ISL-TP well. ISL can be administered to virologically suppressed adults without regard to age, weight, sex, race/ethnicity, or mild/moderate renal impairment. No reduction in efficacy is expected at ISL exposures at a geometric mean ratio of 0.6-fold of those produced by the proposed clinical dose of 0.25 mg QD.

Michelle M. Pham, PhD, Merck & Co., Inc: Full Time employee Michelle C. Fox, MD, Merck & Co., Inc.: Employment|Merck & Co., Inc.: Stocks/Bonds (Public Company) Lihong Du, PhD, Merck & Co., Inc.: Employment|Merck & Co., Inc.: Stocks/Bonds (Public Company) Seth H. Robey, PhD, Merck & Co.,Inc.: Employment|Merck & Co.,Inc.: Stocks/Bonds (Public Company) Munjal Patel, PhD, Merck & Co., Inc.: Employment|Merck & Co., Inc.: Stocks/Bonds (Public Company) Martin Johnson, PhD, Allucent: Stocks/Bonds (Public Company) Stephanie O. Klopfer, PhD, Merck & Co., Inc: Employment|Merck & Co., Inc: Stocks/Bonds (Public Company) Ryan C. Vargo, PhD, Merck and Co.: Full time employee|Merck and Co.: Stocks/Bonds (Public Company) Brian M. Maas, PharmD, Merck & Co. Inc.: Employment|Merck & Co. Inc.: Stocks/Bonds (Public Company)

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