# P-191. Detection of Hearing Loss by Formal Audiological Screening Test in Pediatric and Adult Acute Meningitis: A Global Systematic Review and Meta-analysis

## TL;DR

This study finds that hearing loss in meningitis patients is more commonly detected before discharge than after, suggesting early audiological screening is crucial.

## Contribution

The study provides new insights into optimal timing for audiological screening in meningitis patients to detect hearing loss early.

## Key findings

- Hearing loss diagnoses were more frequent before discharge in both adults and children.
- Pooled prevalence of hearing loss was highest during hospitalization or at discharge (30.4%).
- Standardized auditory evaluations are needed following acute meningitis diagnosis.

## Abstract

Acute community-acquired bacterial meningitis remains a significant global health concern with significant mortality and morbidity, including neurological sequelae such as sensorineural hearing loss (SNHL). Early detection of meningitis-associated SNHL mitigates permanent deafness and poor outcomes. This systematic review evaluates the optimal timing of formal audiological testing in relation to the diagnosis of acute meningitis in adults and children.

A literature search was conducted across Ovid Medline, Elsevier Embase, and Cochrane databases. Studies reporting the time frames for hearing loss (HL) detection secondary to acute meningitis using formal audiological tests were included. Data were analyzed descriptively for continuous and categorical variables. A meta-analysis calculated the pooled prevalence of outcomes, with subgroup analyses stratified by the time frame of audiological screening.

A total of 41 studies were included, with 8,105 meningitis patients comprising 1,397 (17.2%) adults and 6,708 (82.8%) children. In adults, most audiological screenings occurred post-discharge, yet the proportion of hearing loss diagnoses was higher before discharge than after (45.5% vs. 42.5%). Similarly, in children, more screenings were administered post-discharge compared to before (3,340 vs. 1,975), but HL diagnoses were more frequent before discharge. The pooled prevalence of HL diagnoses during hospitalization or at discharge was 30.4% (95% CI 22.9-38%), compared to 22.9% (95% CI 12.6-33.1%) within one-month post-discharge, 20.3% (95% CI 8.8-31.9%) between 30 to 60 days post discharge, 22.7% (95% CI 12.1-33.4%) between 60-180 days post-discharge, and 10.8% (95% CI 10.8-15.7%) after 180 days of discharge.

The considerable variability in the time frame of audiological test administrations following an acute meningitis episode highlights the need for standardized auditory evaluations after meningitis diagnosis. Our findings suggest that early implementation of SNHL screening, particularly before discharge, should be prioritized alongside proper follow-up screening in children and adults.

Kiran T. Thakur, MD FAAN, Center for Disease Control: Grant/Research Support|Delve Bio: Advisor/Consultant|World Health Organization: Advisor/Consultant