# P-1046. Burkholderia Bloodstream Infections In Indian Hospitals: A Multicenter Analysis Of Clinical Burden And Outcomes

## TL;DR

This study examines the clinical impact and outcomes of Burkholderia bloodstream infections in Indian hospitals, highlighting high mortality rates and the need for improved infection control.

## Contribution

The study provides a multicenter analysis of Burkholderia infections in India, emphasizing their burden in public hospitals and association with central line infections.

## Key findings

- Burkholderia cepacia was the most common organism isolated in bloodstream infections.
- Mortality rates were high, with 49.2% of patients dying within the study period.
- Central line-associated bloodstream infections were most prevalent, especially in public hospitals.

## Abstract

Burkholderia species are emerging as significant pathogens in nosocomial bloodstream infections, particularly central line-associated bloodstream infections (CLABSIs). These infections present a clinical challenge due to their association with invasive devices and their prevalence in critical care settings. Understanding the epidemiological trends and outcomes is vital for strengthening infection prevention strategies and resource planning in Indian healthcare facilities.Demographic, Clinical, and Outcome Profile of Patients with Burkholderia Bloodstream Infections (2017–2024)

Demographic, Clinical, and Outcome Profile of Patients with Burkholderia Bloodstream Infections (2017–2024)

This retrospective multicenter study included 802 confirmed cases of Burkholderia bloodstream infections reported between 2017 and 2024 across hospitals under the Indian Council of Medical Research (ICMR) and National Centre for Disease Control (NCDC) networks. Data on demographics, infection type, hospital setting (public vs. private), admission source, clinical outcomes, and unit distribution were analyzed. The study encompassed multispecialty, trauma, and oncology hospitals from various geographic regions of India.

Among the 802 patients, 67.3% were male, and 85.5% had a central line. CLABSI was the most common infection type (81%). Patients were primarily admitted from the home/community (418 cases), followed by referrals from other hospitals (359). The majority of infections (82%) were reported from public hospitals, with the rest from private institutions. Burkholderia cepacia was the predominant organism isolated (728 cases), with smaller numbers of B. pseudomallei, B. cenocepacia, and others. During the 14-day surveillance period, 295 patients (36.8%) died, while the final outcome data showed a mortality of 49.2% (395 patients). A total of 308 patients were discharged, 21 left against medical advice, and 13 were transferred to other hospitals. These findings reflect a high disease burden, especially in patients with central lines and those admitted to public sector hospitals.

Burkholderia bloodstream infections, particularly CLABSIs, are associated with significant morbidity and mortality in Indian hospital settings, predominantly affecting patients in public sector multispecialty units. These findings suggest centralized monitoring to reduce the burden of these healthcare-associated infections.

All Authors: No reported disclosures