P-1516. Impact of a Team-Based Behavioral and Educational Intervention on Influenza and COVID-19 Vaccine Co-Administration During the 2024-2025 Respiratory Virus Season

TL;DR

A team-based education and behavior program increased co-administration of influenza and COVID-19 vaccines in U.S. clinics during the 2024-2025 season.

Contribution

Demonstrates that team-based interventions can effectively boost vaccine co-administration rates among adults.

Findings

Intervention clinics had a 31.4% co-administration rate versus 21.4% in controls (RR, 1.47).

Among adults ≥65 years, co-administration was 32.1% in intervention versus 22.8% in controls (RR, 1.41).

Survey results showed increased vaccine confidence and recommendation behaviors among staff in intervention clinics.

Abstract

Despite national recommendations, adult respiratory vaccination rates in the U.S. remain suboptimal, contributing to preventable morbidity and mortality. Co-administering influenza and COVID-19 vaccines is a practical, yet underutilized strategy to improve uptake.

This project assessed the impact of a team-based behavioral and educational intervention program on influenza and COVID-19 vaccine co-administration. Twenty U.S.-based outpatient clinics serving diverse adult populations were selected for the intervention group and matched to control clinics by vaccination history and demographics. All clinics operated within a technology-enabled vaccine administration ecosystem. Clinic staff (healthcare providers [HCPs] and non-HCPs) at intervention sites participated in the program, consisting of expert-led educational and behavioral interventions. Their perceptions and recommendation behaviors were assessed pre- and post-intervention using a modified Vaccine Confidence Index survey. Adult vaccination data were collected from August 2024 to February 2025. Co-administration rates (receipt of both vaccines within 24 hours) were compared between groups. Chi-square testing and relative risk (RR) estimates with 95% confidence intervals (CI) were calculated.

23,430 and 91,924 adults (≥18 years) received an influenza vaccine in the intervention and control groups, respectively. Of these, 31.4% in intervention clinics and 21.4% in control clinics received a COVID-19 vaccine at the same visit (RR, 1.47; 95% CI, 1.43–1.50; p< 0.001). Among adults ≥65 years, 11,694 and 47,816 received an influenza vaccine in the intervention and control groups, respectively; co-administration rates were 32.1% versus 22.8% (RR, 1.41; 95% CI, 1.37–1.45; p< 0.001). Survey findings showed increased vaccine confidence and recommendation behaviors among intervention clinic staff.

A targeted seasonal program for clinic teams can significantly improve co-administration. These findings underscore the importance of staff behavioral and educational interventions. Further, it highlights their role in reducing missed opportunities for COVID-19 vaccination and strengthening adult immunization efforts.

Tiffany A. Dickey, PharmD, BCIDP, Moderna, Inc.: Employee|Moderna, Inc.: Stocks/Bonds (Public Company) Ruth Carrico, PhD, DNP, APRN, VaxCare: Advisor/Consultant Colm Smart, MBA, VaXcare: Stocks/Bonds (Private Company) Laura Hendrix, MS, Moderna, Inc.: Employee|Moderna, Inc.: Stocks/Bonds (Public Company) Kathryn Lang, MD, PhD, VaxCare: Advisor/Consultant Hagit Kopel, PhD, Moderna, Inc.: Employee|Moderna, Inc.: Stocks/Bonds (Public Company) James A. Mansi, PhD, Moderna, Inc.: Employee|Moderna, Inc.: Stocks/Bonds (Public Company)