# Paraneoplastic Raynaud’s Phenomenon: A Case Report

**Authors:** Beatriz Vitó Madureira, Rita Aranha, Rita Soares Costa

PMC · DOI: 10.7759/cureus.99075 · Cureus · 2025-12-12

## TL;DR

A 63-year-old man with lung cancer developed Raynaud’s phenomenon, suggesting a rare paraneoplastic connection that doctors should consider in similar cases.

## Contribution

This case report highlights paraneoplastic Raynaud’s phenomenon as a rare complication of lung cancer that requires clinical awareness.

## Key findings

- A 63-year-old with stage IV lung cancer developed Raynaud’s phenomenon with no other secondary causes identified.
- The case supports a paraneoplastic origin for the vasospastic symptoms observed.
- Early recognition of such paraneoplastic syndromes can improve symptom management and understanding.

## Abstract

Raynaud’s phenomenon is a vasospastic disorder that may occur as a primary benign condition or as a secondary manifestation of systemic disease. We describe the case of a 63-year-old man, with stage IV squamous cell carcinoma of the left lung undergoing palliative chemotherapy, who developed asymmetric and transient discoloration of the distal upper extremities. The patient’s clinical history of active cancer, combined with exclusion of other secondary causes, supported a paraneoplastic etiology. Paraneoplastic Raynaud’s phenomenon should be considered in adults with atypical or new-onset vasospastic symptoms, especially in the context of established malignancy. Early recognition is essential to optimize symptom management and enhance understanding of paraneoplastic vascular syndromes associated with lung cancer.

## Linked entities

- **Diseases:** squamous cell carcinoma (MONDO:0005096), lung cancer (MONDO:0005138)

## Full-text entities

- **Diseases:** vasospastic disorder (MESH:D009358), systemic disease (MESH:D034721), discoloration (MESH:D014075), stage IV squamous cell carcinoma of the left lung (MESH:D002294), Raynaud's Phenomenon (MESH:D011928), cancer (MESH:D009369), lung cancer (MESH:D008175), Paraneoplastic (MESH:D010257)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12791199/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12791199/full.md

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Source: https://tomesphere.com/paper/PMC12791199