# Double-strand break-free epigenetic programming: a safer path for T-cell therapies

**Authors:** Lanxin Deng, Yujia Yang, Assam El-Osta

PMC · DOI: 10.1038/s41392-025-02529-9 · Signal Transduction and Targeted Therapy · 2026-01-12

## Full-text entities

- **Genes:** CD151 (CD151 molecule (Raph blood group)) [NCBI Gene 977] {aka EBS7, GP27, MER2, PETA-3, RAPH, SFA1}, RASA2 (RAS p21 protein activator 2) [NCBI Gene 5922] {aka GAP1M}, TET1 (tet methylcytosine dioxygenase 1) [NCBI Gene 80312] {aka CXXC6, LCX, bA119F7.1}, PDCD1 (programmed cell death 1) [NCBI Gene 5133] {aka ADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2}, TRAC (T cell receptor alpha constant) [NCBI Gene 28755] {aka IMD7, TCRA, TRCA}, FOXP3 (forkhead box P3) [NCBI Gene 50943] {aka AIID, DIETER, IPEX, JM2, PIDX, XPID}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, CXADRP1 (CXADR pseudogene 1) [NCBI Gene 653108] {aka CAR, CXADRP}
- **Diseases:** toxicity (MESH:D064420), infectious disease (MESH:D003141), tumor (MESH:D009369), beta-thalassaemia (MESH:D017086), autoimmune indications (MESH:D001327), SCD (MESH:D000755), B-cell malignancies (MESH:D016393), vaso-occlusive crises (MESH:D013224), rare disease (MESH:D035583), TDT (MESH:D065227)
- **Chemicals:** CASGEVY (-), THAL- (MESH:D013792), 5-methylcytosine (MESH:D044503)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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## References

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Source: https://tomesphere.com/paper/PMC12791138