# Linear IgA Bullous Dermatosis in an Elderly Patient Following Meloxicam and Candesartan Use: A Case Report

## TL;DR

An elderly woman developed a rare skin condition after taking meloxicam and candesartan, which improved after stopping the drugs and using dapsone.

## Contribution

This case report highlights drug-induced Linear IgA Bullous Dermatosis and emphasizes the importance of drug history in diagnosis.

## Key findings

- A 61-year-old woman developed Linear IgA Bullous Dermatosis after using meloxicam and candesartan.
- Discontinuation of the drugs and treatment with dapsone led to clinical improvement.
- The case emphasizes the need for careful drug history and early recognition of drug-induced dermatosis.

## Abstract

Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune blistering disorder characterized by subepidermal blisters and linear IgA deposition along the dermo-epidermal junction (DEJ). We report the case of a 61-year-old woman who developed multiple tense vesicles and bullae on an erythematous base affecting both upper and lower extremities after initiating meloxicam for postoperative analgesia following knee arthroplasty. A punch biopsy showed subepidermal blistering, while direct immunofluorescence demonstrated linear IgA deposition along the basement membrane zone, confirming LABD. After discontinuation of the suspected culprit drug and adjustment of her antihypertensive therapy, she was treated with oral dapsone 1 mg/kg (50 mg) daily for two weeks, resulting in clinical improvement. This case underscores the importance of thorough drug history taking and early recognition of drug-induced LABD, particularly in patients on multiple medications, where identifying the true offending agent may be challenging.