# A Case of Mandibular Osteomyelitis Occurring in a Patient With Parry-Romberg Syndrome

## TL;DR

This paper reports a rare case of jawbone infection in a patient with Parry-Romberg syndrome and explores possible contributing factors.

## Contribution

The paper presents a unique case linking mandibular osteomyelitis with Parry-Romberg syndrome and discusses potential pathogenic mechanisms.

## Key findings

- Mandibular osteomyelitis occurred in a patient with Parry-Romberg syndrome.
- Autoimmune disease and trauma may contribute to the progression of PRS.
- Neurovascular and neuroskeletal dysregulation could play a role in PRS pathogenesis.

## Abstract

Progressive hemifacial atrophy, also known as Parry-Romberg syndrome (PRS), is an idiopathic disorder characterized by progressive unilateral facial depression caused by atrophy of the skin and subcutaneous tissue. We present a case of mandibular osteomyelitis occurring in a patient with this condition, together with a review of the literature. The clinical findings in this case suggest that autoimmune disease and trauma are involved in contributing factors to disease progression. Possible involvement of neurovascular and neuroskeletal dysregulations in the pathogenesis of PRS is also discussed.