# From Years of Pain to a Name: Fibromyalgia Uncovered

**Authors:** Sara Ali, Archana Banda, Carlos Ramirez-Matos, Peter Cohen

PMC · DOI: 10.7759/cureus.98981 · Cureus · 2025-12-11

## TL;DR

This paper presents a complex case of a woman with chronic pain and multiple health issues ultimately diagnosed with fibromyalgia.

## Contribution

The paper highlights the diagnostic challenges of fibromyalgia in the presence of multiple comorbidities and emphasizes the importance of patient advocacy.

## Key findings

- Fibromyalgia was diagnosed after ruling out other common causes of chronic pain.
- The patient had multiple comorbidities that complicated the diagnostic process.
- A multimodal treatment approach is essential for managing fibromyalgia.

## Abstract

Fibromyalgia is a chronic multisystem disorder marked by widespread pain, fatigue, and sleep and mood disturbances, predominantly affecting women. Its multifactorial etiology and diagnosis by exclusion often delay recognition. A multimodal approach, with reassurance, shared treatment goals, education, cognitive behavioral therapy (CBT), and exercise, is critical. Effective pharmacologic options include duloxetine, milnacipran, pregabalin, and amitriptyline. This report describes a female in her late thirties who presented to the clinic with chronic widespread pain. Her past medical history was significant for a motor-vehicle accident four months ago, bipolar II disorder, major depressive disorder, post-traumatic stress disorder, irritable bowel syndrome, cardiomyopathy, stage 3 chronic kidney disease, hidradenitis suppurativa, and melanoma. When repeated laboratory tests and imaging failed to provide answers, it became increasingly clear that this patient's case was particularly challenging to diagnose, especially due to existing comorbidities. However, after ruling out the common causes for diffuse chronic pain, fibromyalgia was diagnosed. This case illuminates the importance of clinicians being patient advocates throughout the journey and listening attentively to patients' concerns even when laboratory results and imaging appear unremarkable.

## Linked entities

- **Diseases:** fibromyalgia (MONDO:0005546), bipolar II disorder (MONDO:0000693), major depressive disorder (MONDO:0002009), post-traumatic stress disorder (MONDO:0005146), irritable bowel syndrome (MONDO:0005052), cardiomyopathy (MONDO:0004994), chronic kidney disease (MONDO:0005300), hidradenitis suppurativa (MONDO:0006559), melanoma (MONDO:0005105)

## Full-text entities

- **Diseases:** chronic pain (MESH:D059350), irritable bowel syndrome (MESH:D043183), stage 3 chronic kidney disease (MESH:D007676), sleep and mood disturbances (MESH:D019964), depressive disorder (MESH:D003866), Pain (MESH:D010146), post-traumatic stress disorder (MESH:D013313), cardiomyopathy (MESH:D009202), hidradenitis suppurativa (MESH:D017497), fatigue (MESH:D005221), Fibromyalgia (MESH:D005356), bipolar II disorder (MESH:D001714), melanoma (MESH:D008545)
- **Chemicals:** amitriptyline (MESH:D000639), pregabalin (MESH:D000069583), duloxetine (MESH:D000068736), milnacipran (MESH:D000078764)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12790412/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12790412/full.md

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Source: https://tomesphere.com/paper/PMC12790412