# Multiple Left Ventricular Ball Thrombi in a Patient With Nonischemic Cardiomyopathy Bridged to Heart-Lung Transplantation

**Authors:** Adam Zviman, Julie Zviman, Sarah Cipriano, Allen Burke, Manjula Ananthram

PMC · DOI: 10.1016/j.jaccas.2025.105488 · JACC Case Reports · 2025-09-18

## TL;DR

A patient with severe heart failure and a large heart clot was successfully treated with a heart-lung transplant.

## Contribution

This case highlights successful management of complex heart failure and thrombus via heart-lung transplantation.

## Key findings

- A patient with nonischemic cardiomyopathy and a large left ventricular thrombus was treated with heart-lung transplant.
- Combined heart-lung transplantation successfully managed cardiogenic shock and severe pulmonary hypertension.
- The patient had an uneventful recovery after the transplant.

## Abstract

We present a case of a young patient with a history of recurrent venous thromboembolism, stroke status post fibrinolysis, and titin-related dilated cardiomyopathy who developed cardiogenic shock in the setting of decompensated heart failure and concomitant large left ventricular thrombus comprising ∼75% of the cavity. Her shock was managed medically as she was evaluated for surgical heart failure therapies. The patient underwent a combined heart-lung transplant and was discharged after an uneventful postoperative course.

This case demonstrates that concomitant end-stage heart failure, large intracardiac thrombus, and severe pulmonary hypertension can be managed successfully with combined heart-lung transplantation.

## Linked entities

- **Diseases:** dilated cardiomyopathy (MONDO:0005021), cardiogenic shock (MONDO:0800175), pulmonary hypertension (MONDO:0005149)

## Full-text entities

- **Genes:** TTN (titin) [NCBI Gene 7273] {aka CMD1G, CMH9, CMPD4, CMYO5, CMYP5, EOMFC}
- **Diseases:** end-stage heart failure (MESH:D007676), Left Ventricular Ball Thrombi (MESH:D018487), heart failure (MESH:D006333), intracardiac thrombus (MESH:D013927), cardiogenic shock (MESH:D012770), stroke (MESH:D020521), dilated cardiomyopathy (MESH:D002311), shock (MESH:D012769), pulmonary hypertension (MESH:D006976), Nonischemic Cardiomyopathy (MESH:D009202), venous thromboembolism (MESH:D054556)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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Source: https://tomesphere.com/paper/PMC12790197