# Visceral Adipose Tissue Shows Stronger Links to both Chronological and MRI Predicted Brain Age Compared to Subcutaneous Adipose Tissue

## TL;DR

Visceral fat is more strongly linked to brain aging and Alzheimer's risk than subcutaneous fat, based on MRI data from over 1,000 participants.

## Contribution

This study shows that visceral adipose tissue has stronger associations with brain age than subcutaneous adipose tissue.

## Key findings

- Visceral adipose tissue (VAT) is more strongly correlated with chronological and brain age than subcutaneous adipose tissue (SAT).
- VAT showed a stronger link to brain age (r=0.28) compared to SAT (r=0.09), even after adjusting for sex.
- No significant association was found between VAT/SAT and brain age gap (BAG).

## Abstract

Brain age – an image derived measure from structural brain images on T1 weighted scans may reveal information on Alzheimer's risk. We have previously shown that increased abdominal adipose tissue relates to brain atrophy. We evaluated the links between abdominal adipose tissue and brain age.

A total of 1,164 healthy participants from four sites (mean chronological age 55.17 ± 12.37 years, 52% women; 48% men; 39% non‐white) were scanned on 1.5T MR machines with a whole‐body protocol. Whole body sequences utilized in the quantitative analyses of abdominal fat were coronal T1 were used to segment visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) segmentation. In this process, a nnU‐Net model was used for fully supervised segmentation and ITK‐SNAP was used for manual annotation. Brain age was computed using a regression‐based 3D Simple Fully Convolutional Network. The model was trained on in‐house T1‐weighted MRI scans collected from 5,500 healthy individuals, aged 18 to 89 years. Brain age gap (BAG) was computed by subtracting chronological age from brain age. Bivariate correlations between VAT and SAT to chronological and brain age were done with partial correlations adjusted for sex with brain age. VAT and SAT were normalized to total abdominal body fat volume. Chronological age was not adjusted for in brain age models to avoid collinearity.

Mean brain age exceeded chronological age (mean brain age = 56.04 ± 12.65, mean BAG = 0.69) and were highly correlated (r=0.94, p <.001). VAT and SAT were positively related to increased chronological age (VAT: r=0.2780, p = 5.477e‐20; r=0.0924, p = 0.002817) and increased brain age (VAT: r=0.2806, p = 2.42e‐20; SAT: r=0.0947, p = 0.002189) with VAT being more closely linked to age than SAT. This did not change when adjusting for sex in separate partial correlations between VAT and SAT for brain age (VAT: rp = r=0.2948, p = 2.247e‐22; SAT: r=0.1070, p = 0.0005353). No statistically significant link was noted with VAT, SAT, and BAG.

Both VAT and SAT are linked to chronological and brain age with VAT being more strongly linked. VAT may be a key target for modifying brain age and Alzheimer's risk.

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Source: https://tomesphere.com/paper/PMC12790093