# Effects of a smartphone-based chatbot intervention on influenza and COVID-19 vaccine uptake among South Asians

**Authors:** Cho Lee Wong, Dorothy Ngo Sheung Chan, Winnie Kwok Wei So, Carmen Wing Han Chan, Kai Chow Choi, Huiyuan Li, Shelby L Garner

PMC · DOI: 10.1038/s41746-025-02200-1 · NPJ Digital Medicine · 2025-12-11

## TL;DR

A smartphone chatbot helped South Asians get flu and COVID-19 vaccines more than a wait-list control group.

## Contribution

A chatbot intervention was tested and shown to boost vaccine uptake in South Asian minorities.

## Key findings

- Influenza vaccination rates were 57.8% in the intervention group immediately after the chatbot use.
- Three months later, 68.0% of the intervention group had received the flu vaccine.
- The control group had very low vaccination rates (1.3% and 2.0%) compared to the intervention group.

## Abstract

Smartphone-based chatbot interventions have shown promise in promoting vaccine uptake among South Asian minorities. In this two-arm, cluster-randomised, wait-list controlled trial (Chinese Clinical Trial Registry: ChiCTR2200061503; registration date: June 27th, 2022), South Asians (aged 18 or older, from Pakistan, India, or Nepal) who had not received influenza or COVID-19 vaccines in the past year were randomly assigned at the cluster level to intervention or wait-list control groups. The intervention comprised a simple rule-based chatbot integrated into the smartphone application and an on-demand feature allowing users to connect with trained research assistants. Among 610 participants analysed, influenza vaccination rates were significantly higher in the intervention group than the control group immediately after (57.8% vs. 1.3%, p < 0.001) and three months post-intervention (68.0% vs. 2.0%, p < 0.001). Our results suggested that smartphone-based chatbot intervention could be an effective strategy to increase vaccination rates among South Asian ethnic minorities.

## Linked entities

- **Diseases:** influenza (MONDO:0005812), COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** influenza (MESH:D007251), COVID-19 (MESH:D000086382)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12789578/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12789578/full.md

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Source: https://tomesphere.com/paper/PMC12789578