# The testobolome in microbial testosterone metabolism and human health

## TL;DR

This paper introduces the concept of the testobolome, gut bacteria that metabolize testosterone, and explores its potential impact on human health and hormone balance.

## Contribution

The paper introduces the novel term 'testobolome' and outlines a framework for studying microbiome-mediated testosterone metabolism.

## Key findings

- Testosterone is metabolized by gut bacteria in ways similar to estrogens.
- The testobolome may influence host hormone homeostasis and health outcomes.
- The paper identifies known members of the testobolome and suggests future research directions.

## Abstract

We propose the term testobolome, analogous to the estrobolome, to describe gut bacteria that metabolize testosterone. Testosterone undergoes microbial transformations similar to estrogens, potentially influencing host hormone homeostasis and health. This review defines the testobolome, identifies its known members, and explores mechanisms that are shared or distinct from the estrobolome. We outline a framework for future research into microbiome-mediated steroid metabolism, including its role in aging and hormone-driven diseases.