# Clinical and Genotypic Features of Norovirus Enteritis in Children Complicated by Convulsions: A Retrospective Study in Kunming, China

## TL;DR

This study explores the clinical and genetic features of norovirus enteritis in children who experience convulsions, identifying risk factors and genotypes in Kunming, China.

## Contribution

The study provides new insights into the molecular epidemiology and clinical risk factors of norovirus enteritis complicated by convulsions.

## Key findings

- Elevated serum CK-MB levels and fever are independent risk factors for convulsions in NoVE patients.
- Lower frequency of diarrhea acts as a protective factor against convulsions in NoVE.
- GII.4 genotype is the most prevalent in both NoVE and NoVE with convulsion groups.

## Abstract

Although studies have described the clinical characteristics of norovirus enteritis (NoVE) associated with convulsions, research on its molecular epidemiology remains limited. Therefore, this study aimed to investigate both the clinical manifestations and genotypic features of NoVE complicated by convulsions.

NoVE children admitted to our hospital between November 2021 and May 2022 were divided into NoVE complicated with convulsion group and NoVE group. Then, we screened the risk factors of NoVE complicated with convulsion based on multivariate regression analysis. The stool samples were collected, followed by amplification of VP1 sequences of GI and GII and phylogenetic analysis of VP1 in both groups.

Logistic regression analysis showed that elevated serum CK‐MB levels and fever were independent risk factors for convulsions in NoVE patients, while a lower frequency of diarrhea was an independent protective factor. GII.3 genotype was merely detected in 12 NoVE samples (14.81%) and was detected in 5 (15.19%) NoVE with convulsion samples. The GII.4 genotype was detected in 28 (84.85%) samples of the NoVE with convulsion group and 69 (85.19%) samples from the NoVE group.

Elevated serum CK‐MB concentration, fever, and frequency of diarrhea were independent influencing factors for NoVE complicated by convulsions.