# Dual roles of circadian clock proteins in development and adult homeostasis

## TL;DR

This paper explores how circadian clock proteins affect development and adult health, highlighting their dual roles and potential for stage-specific treatments.

## Contribution

The paper provides a comprehensive review of BMAL1 and REV-ERBα/β roles across life stages and proposes mechanisms for their dual involvement.

## Key findings

- BMAL1 and REV-ERBα/β influence skeletal formation and metabolic programming during embryogenesis.
- These proteins maintain tissue integrity and metabolic adaptation in adulthood.
- Disruption of circadian components leads to distinct phenotypes depending on the life stage.

## Abstract

Circadian clocks coordinate physiology with daily cycles. Loss of circadian components disrupts bodily functions, but the phenotypes differ when disruption occurs during development or adulthood. Here, we compare effects of manipulating mammalian clock proteins across life stages, reviewing roles of BMAL1 and REV-ERBα/β in embryogenesis—skeletal formation, metabolic programming, cardiovascular development—and adulthood—tissue integrity, metabolic adaptation, neuroprotection. We further discuss mechanisms for dual involvement, and implications for stage-specific therapies.