# Global burden and projections of cervical cancer attributable to unsafe sex and smoking, 1990–2034

## TL;DR

This study examines how unsafe sex and smoking contribute to cervical cancer deaths worldwide from 1990 to 2034, highlighting regional differences and the need for targeted prevention.

## Contribution

The study projects future cervical cancer trends by linking risk factors like unsafe sex and smoking to sociodemographic index levels.

## Key findings

- Unsafe sex is the leading risk factor for cervical cancer, especially in low-SDI regions.
- By 2034, cervical cancer mortality attributed to unsafe sex and smoking is projected to decrease globally but increase in specific regions like India and China.
- Targeted interventions such as HPV vaccination and smoking cessation are critical in low SDI areas.

## Abstract

To analyze global trends and attributable risks (smoking and unsafe sex) in disease burden of cervical cancer from 1990 to 2034, considering different sociodemographic index (SDI) levels.

Data from the Global Burden of Disease 2019 study was utilized. Quantile regression, restricted cubic spline, and Nordpred models were applied to analyze the relationship between cervical cancer age-standardized mortality rates (ASMRs), age-standardized Disability-Adjusted Life Years rates (ASDRs) and SDI, and predicted future trends.

From 1990 to 2019, global cervical cancer ASMR declined but the total deaths increased. Unsafe sex accounted for the highest disease burden, particularly in low-SDI regions, followed by smoking. By 2034, ASMR attributed to unsafe sex and smoking is projected to further decrease globally, but an upward trend is expected in specific regions including India (unsafe sex), China (smoking) and Russian Federation (unsafe sex and smoking).

Unsafe sex is the leading risk factor for cervical cancer. Targeted strategies are needed for distinct age groups: enhanced prevention and screening for those aged 55–59 years, and optimized care for adults aged over 95 years. The key interventions, including HPV vaccination, screening, and smoking cessation programs, remain critical in low and low-middle SDI areas.