# A Review on Hierarchical Nanostructures for Electrochemical Sensors

**Authors:** Safia Dassallem, Khalid Nouneh, Yanpeng Xue, Domenica Tonelli, Abdelhafed Taleb

PMC · DOI: 10.3390/s26010073 · Sensors (Basel, Switzerland) · 2025-12-22

## TL;DR

This paper reviews how hierarchical nanostructures improve electrochemical sensors by enhancing performance through unique material properties.

## Contribution

The paper provides a comprehensive review of synthesis strategies and performance characteristics of hierarchical nanomaterials in electrochemical sensors.

## Key findings

- Hierarchical nanomaterials offer abundant diffusion channels and high surface area for better sensor performance.
- Various synthesis techniques significantly influence the properties of hierarchical nanomaterials.
- These materials show promise but face challenges in electroanalytical applications.

## Abstract

In recent years, researchers have significantly increased their exploration of nanomaterials, primarily due to their exceptional and distinctive electrochemical properties. Hierarchical nanostructured materials have become a prevalent component in electrochemical sensors owing to their numerous advantages, including abundant open diffusion channels, diverse junction interfaces, and a highly exposed surface area. This review provides a comprehensive overview of the potential of hierarchical nanomaterials as electrode modifiers, highlighting their capacity to enhance device performance. The introduction section sets the context by addressing the challenges and recent advancements in the field of hierarchical nanomaterials, emphasizing their promise for electrochemical sensor applications, and outlining the diverse research directions that are currently being explored. In the following section, a range of strategies and techniques for synthesizing hierarchical nanomaterials are outlined, with an emphasis on the impact of various parameters on their properties. Subsequently, the characteristics and performance of diverse hierarchical nanomaterials as electrode modifiers for electrochemical sensor applications are examined. Ultimately, the primary aspects and challenges of hierarchical nanomaterials in the domain of electroanalysis are reported, followed by a discussion of their future development.

## Full-text entities

- **Genes:** MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}, AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}, PTX3 (pentraxin 3) [NCBI Gene 5806] {aka TNFAIP5, TSG-14}, APOE (apolipoprotein E) [NCBI Gene 348] {aka AD2, APO-E, ApoE4, LDLCQ5, LPG}, CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}
- **Diseases:** ovarian cancer (MESH:D010051), GCEs (MESH:C536823), COVID-19 (MESH:D000086382), toxicity (MESH:D064420), injury to (MESH:D014947), Cancer (MESH:D009369)
- **Chemicals:** ruthenium dioxide (MESH:C029017), citrate (MESH:D019343), TiO2 (MESH:C009495), Co (MESH:D003035), sucrose (MESH:D013395), titanium carbide (MESH:C096521), indium (MESH:D007204), vitamin B6 (MESH:D025101), Ga (MESH:D005708), DA (MESH:D004298), tramadol (MESH:D014147), CdS (MESH:D002104), MXene (MESH:C000723374), arsenic (MESH:D001151), hydrogen (MESH:D006859), glucose (MESH:D005947), Mn (MESH:D008345), NPS (MESH:D009405), Mg (MESH:D008274), DMSO (MESH:D004121), Fe3O4@SiO2 (-), H2O2 (MESH:D006861), tyramine (MESH:D014439), Gr (MESH:D006108), CF (MESH:D002142), aluminum (MESH:D000535), S (MESH:D013455), CuO (MESH:C030973), NiO (MESH:C028007), SiO2 (MESH:D012822), MOF (MESH:C037042), glycerol (MESH:D005990), Ru (MESH:D012428), Tungsten trioxide (MESH:C511604), CNT (MESH:D037742), Ni3+ (MESH:C043282), Nafion (MESH:C040402), nitrite (MESH:D009573), 4-nitrophenol (MESH:C024836), riboflavin (MESH:D012256), nalbuphine (MESH:D009266), amine (MESH:D000588), oxazepam (MESH:D010076), acetone (MESH:D000096), sotalol (MESH:D013015), MnO2 (MESH:C016552), Zinc oxide (MESH:D015034), polyaniline (MESH:C416807), water (MESH:D014867), Palladium (MESH:D010165), tyrosine (MESH:D014443), diclofenac (MESH:D004008), sodium borohydride (MESH:C025364), PMMA (MESH:D019904), f (MESH:D005461), In2O3 (MESH:C047711), CC (MESH:C034221), Fe (MESH:D007501), fullerenes (MESH:D037741), NiFe2O4 (MESH:C550717)
- **Species:** PX clade (clade) [taxon 569578], Homo sapiens (human, species) [taxon 9606], Escherichia coli O157:H7 (no rank) [taxon 83334], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932]

## Full text

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## Figures

17 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12788060/full.md

## References

132 references — full list in the complete paper: https://tomesphere.com/paper/PMC12788060/full.md

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Source: https://tomesphere.com/paper/PMC12788060