# Synthesis of Cobalt Hydroxychloride and Its Application as a Catalyst in the Condensation of Perimidines

## TL;DR

This paper describes a new method to make cobalt hydroxychloride, which efficiently catalyzes the production of perimidines under green chemistry conditions.

## Contribution

The synthesis and application of cobalt hydroxide chloride as a reusable catalyst for perimidine condensation is novel.

## Key findings

- The catalyst achieved high yields (64–99%) and short reaction times in perimidine synthesis.
- The catalyst was successfully recycled and reused without significant performance loss.
- Gram-scale synthesis of dihydroperimidines was achieved with an 89% yield.

## Abstract

Herein, we report the synthesis, characterization, and catalytic evaluation of cobalt hydroxide chloride [Co2(OH)3Cl] in the solvent-free synthesis of 2-substituted 2,3-dihydroperimidines. The presented method aligns with several green chemistry principles, offering operational simplicity, purification by recrystallization, no by-product formation, high yields (64–99%), and short reaction times. A total of 16 dihydroperimidines were synthesized to demonstrate substrate scope versatility. Additionally, the catalyst was successfully recycled and reused in multiple cycles without significant loss. Its robustness was further confirmed by gram-scale synthesis, achieving an 89% yield.