# The Use of Benzoin as a Privileged Structure: Synthesis, Characterization, Crystalline Form and an In Vitro Biological Evaluation of 1,2-Diphenyl-2-[1,2,3]triazol-1-yl-ethanol Derivatives

## TL;DR

This paper explores the synthesis and biological evaluation of new compounds based on benzoin, showing potential antimicrobial and anticancer properties.

## Contribution

The study introduces a novel synthetic approach using benzoin and CuAAC to create 1,2-diphenyl-2-[1,2,3]triazol-1-yl-ethanol derivatives with antimicrobial and antiproliferative activities.

## Key findings

- The compounds showed antimicrobial activity against Candida albicans and Staphylococcus aureus.
- Some derivatives exhibited antiproliferative effects on various tumor cell lines.
- Single-crystal X-ray diffraction confirmed the structure and revealed O-H···N interactions.

## Abstract

A collection of 40 derivatives of 1,2-diphenyl-2-[1,2,3]triazol-1-yl-ethanol was obtained through a sequence of reactions, starting with benzoin as the initial raw material and using the CuAAC reaction as the key step in this process. The structure of a pair of these compounds was ultimately corroborated by single-crystal X-ray diffraction studies, which also reveals important O-H···N interactions. The antimicrobial activity of synthesized 1,2,3-triazoles was assessed against strains that include Candida albicans and Staphylococcus aureus. The antiproliferative properties of some of these novel compounds were also tested using a variety of tumor cell lines, including U251 (human glioblastoma), PC-3 (human prostate cancer cell line), K562 (human leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), and SKLU (human lung adenocarcinoma).