# Fibrin Glues: Proteins, Mechanism of Action, Classification, and Application

## TL;DR

This paper reviews fibrin glues, their mechanisms, and applications in surgery, highlighting their use with biologically active substances to improve healing.

## Contribution

The paper presents new insights into combining fibrin glues with biologically active substances to enhance their therapeutic effectiveness.

## Key findings

- Fibrin glues are biocompatible and effective for hemostasis in surgical settings.
- Combining fibrin glues with biologically active substances improves their therapeutic outcomes.
- New formulations of fibrin glues with adjustable properties are being developed for long-term use.

## Abstract

This research paper is concerned with fibrin glues, used as effective tools to stop bleeding in the case of wounds and surgical interventions. The paper provides data on the various fibrin glues—both currently used in practice and being developed, their sources, mechanisms of action, and properties. Such glues are biocompatible and are characterized by good adhesive and hemostatic properties. These characteristics mean that fibrin glues are currently widely used across a range of surgical applications. Such glues can be used independently or in combination with mechanical techniques, being particularly suitable for difficult-to-access parts of the body. The combined use of fibrin glues with various biologically active substances (BASs)—such as antibiotics and growth factors—and with cell therapy is a promising approach. Such adjuncts enhance the effectiveness of the glues and help to optimize the therapies. This research paper presents the latest data from studies using various experimental models demonstrating the increased efficacy of fibrin glues used in combination with BASs. We also report on the ongoing development of new fibrin glues for long-term use and with optimized formulations. Studies on the interactions of these glues with cells and tissues are supporting the creation of a new generation of fibrin glues with adjustable properties.