# Recent Advances in Ent-Abietane Diterpenes: Natural Sources, Biological Activities and Total Synthesis

## TL;DR

This paper reviews ent-abietane diterpenes, their natural sources, biological activities, and synthesis methods from 2016 to 2025.

## Contribution

The paper presents a comprehensive summary of recent discoveries and synthesis methods for ent-abietane diterpenoids.

## Key findings

- Ent-abietane diterpenoids have a unique tricyclic structure and diverse biological activities.
- Recent studies have identified many new ent-abietane diterpenoids with structural complexity.
- The paper covers advances in the total synthesis of these compounds up to early 2025.

## Abstract

Ent-abietane diterpenoids constitute a class of terpenes with a C20 carbon skeleton that underlie a wide range of biological activities. Ent-abietane diterpenoids, enantiomeric to the abietane counterparts, represent a family of diterpenoid natural products characterized by their distinct 6/6/6 tricyclic carbocyclic skeletons with exceptional structural complexity. An increasing number of these ent-abietane diterpenoids have recently been identified, constituting a well-defined group of naturally occurring compounds. This review provides a comprehensive summary of the natural sources, chemical structures, biological profiles and total synthesis of these ent-abietane diterpenoids from 2016 to early 2025.