# Multimodality Imaging in Cardiac Amyloidosis

**Authors:** Mayuresh Chaudhari, Mahi Lakshmi Ashwath

PMC · DOI: 10.3390/jcm15010163 · Journal of Clinical Medicine · 2025-12-25

## TL;DR

This paper reviews how combining different imaging techniques improves the diagnosis and treatment of heart disease caused by amyloid deposits.

## Contribution

The paper emphasizes the integration of multimodal imaging for better diagnosis and management of cardiac amyloidosis.

## Key findings

- Multimodal imaging improves diagnostic accuracy in cardiac amyloidosis.
- Each imaging modality has unique strengths in detecting and monitoring amyloidosis.
- Integrated imaging guides prognosis and treatment decisions for AL and ATTR amyloidosis.

## Abstract

Cardiac amyloidosis is an underdiagnosed cause of heart failure characterized by extracellular deposition of misfolded proteins. Advances in non-invasive imaging, including echocardiography, cardiac magnetic resonance imaging (CMR), and radionuclide imaging, have significantly enhanced the diagnostic accuracy and monitoring of cardiac amyloidosis. This review explores the role of each modality, their individual strengths, and current consensus recommendations. Emphasis is placed on the integration of multimodal imaging to guide diagnosis, prognosis, and therapeutic decisions in both AL and ATTR amyloidosis.

## Linked entities

- **Diseases:** heart failure (MONDO:0005252)

## Full-text entities

- **Diseases:** ATTR amyloidosis (MESH:D000686), AL (MESH:D009101), heart failure (MESH:D006333)

## Full text

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## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12786694/full.md

## References

104 references — full list in the complete paper: https://tomesphere.com/paper/PMC12786694/full.md

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Source: https://tomesphere.com/paper/PMC12786694