# Flavonoids in Plants and Human Health: From Biosynthesis to Neurodevelopmental and Neurodegenerative Disorders

## TL;DR

Flavonoids are plant compounds with diverse health benefits, including protection against neurodegenerative diseases and chronic conditions.

## Contribution

This review highlights the biosynthesis, chemical properties, and health benefits of flavonoids, emphasizing their potential in disease prevention.

## Key findings

- Flavonoids show antioxidant, anti-inflammatory, and neuroprotective effects.
- They are linked to reduced risks of cardiovascular and neurodegenerative diseases.
- Biotic and abiotic factors influence flavonoid function in plants.

## Abstract

Flavonoids are a class of natural plant compounds that are categorised within the polyphenolic group. It is widely acknowledged that their structural diversity results in a wide distribution within food sources, thus leading to a concomitant wide spectrum of biological activity. This review provides an updated overview of the main flavonoid subclasses, including flavonols, flavones, flavanones, flavanols, anthocyanins, and isoflavones, and includes an examination of their chemical properties and biosynthetic pathways. The present study will discuss the influence of biotic and abiotic factors on flavonoid function in plants, including their role in ultraviolet protection, stress tolerance, and defence signalling. The regular consumption of foods rich in flavonoids has been demonstrated to be associated with a reduced risk of chronic diseases, including cardiovascular, metabolic diseases, neurodegenerative and neurodevelopmental disorders. This observation underscores the significance of flavonoids in a balanced diet. Medicinal plants play an important role in this task. The mechanisms of action of this substance include antioxidant and anti-inflammatory effects, modulation of signalling pathways, and neuroprotective functions. The present findings underscore the significance of flavonoids as multifunctional bioactive molecules, which hold considerable potential for preventive and therapeutic applications. However, further well-designed human studies are necessary to determine effective dosage, long-term safety, and clinical relevance.