# Modular Model of Neuronal Activity That Captures the Dynamics of Main Molecular Targets of Antiepileptic Drugs

## TL;DR

This paper introduces a modular model of neuronal activity that simulates how antiepileptic drugs affect key molecular targets in the brain.

## Contribution

The novelty lies in integrating multiple molecular mechanisms into a single model to capture drug effects on epilepsy-related processes.

## Key findings

- The model accurately simulates ion current and receptor dynamics relevant to epilepsy.
- Simulations show consistent inhibitory effects on synaptic transmission, matching experimental data.
- The model incorporates glutamate and GABA neurotransmitter interactions crucial for neural regulation.

## Abstract

This paper presents a modular mathematical model of neuronal activity, designed to simulate the dynamics of main molecular targets of antiepileptic drugs and their pharmacological effects. The model was developed based on several existing synaptic transmission models that capture cellular processes crucial to the pathology of epilepsy. It incorporates the primary molecular mechanisms involved in regulating excitation and inhibition within the neural network. Special attention is given to the dynamics of ion currents (Na+, K+, Ca2+), receptors (AMPA, NMDA, GABAA, GABAB and mGlu), and neurotransmitters (glutamate and GABA). Examples of simulations illustrating the inhibitory effects on synaptic transmission are provided. The numerical results are consistent with experimental data reported in the literature.