# Development of a Prognostic Nomogram in Epithelial Ovarian Cancer Based on KELIM: A Retrospective Study at TuDu Hospital, Vietnam

## TL;DR

This study develops a survival prediction tool for ovarian cancer patients in Vietnam using factors like KELIM and tumor stage.

## Contribution

A novel prognostic nomogram for epithelial ovarian cancer patients in Vietnam based on KELIM and clinical variables.

## Key findings

- KELIM < 1, elevated CA-125, advanced tumor stage, and residual tumor were significant survival predictors.
- The nomogram integrates these variables to provide personalized prognostic assessments for EOC patients.
- Cumulative mortality rates increased from 1.4% at 1 year to 16.5% at 5 years.

## Abstract

Background/Objectives: Epithelial ovarian cancer (EOC) constitutes the predominant form of ovarian malignancies. The primary goal of this study was to determine predictors of patient survival and construct a nomogram for survival prediction in individuals diagnosed with epithelial ovarian cancer. Methods: A retrospective cohort analysis was performed, including 418 patients who received treatment for epithelial ovarian cancer at Tu Du Hospital from January 2015 to December 2019. The median follow-up time was 77.1 months (range: 5.7–121.6 months). Survival analyses were conducted using the log-rank test and Cox proportional hazard regression analysis. A nomogram was developed, incorporating KELIM and other statistically significant variables. Results: The median follow-up time was 77.1 months. The observed cumulative mortality rates were 1.4% (95% confidence interval [CI]: 0.7–3.2), 10.4% (95% CI: 7.8–13.8), and 16.5% (95% CI: 13.2–20.6) at 1, 3, and 5 years, respectively. Factors demonstrating a significant correlation with survival included KELIM < 1 (HR = 1.78 [95% CI: 1.16–2.72]), pre-treatment CA-125 levels ≥ 35 U/mL (HR = 2.47 [95% CI: 1.10–5.55]), FIGO stages III-IV (HR = 2.40 [95% CI: 1.36–4.21]), and the presence of residual tumor tissue following surgical intervention (HR = 3.14 [95% CI: 1.75–5.65]). Conclusions: Prognosis is significantly influenced by KELIM, pre-treatment CA-125, tumor stage, and residual tumor post-surgery. The nomogram developed here offers a tool to assist in personalized prognostic assessments of Vietnamese EOC patients.