# Special Issue “Ion Channels as a Therapeutic Target: Drug Design and Pharmacological Investigation 2.0

**Authors:** Gabriella Guerrini, Maria Paola Giovannoni

PMC · DOI: 10.3390/ijms27010395 · International Journal of Molecular Sciences · 2025-12-30

## Full-text entities

- **Genes:** Trpm8 (transient receptor potential cation channel, subfamily M, member 8) [NCBI Gene 171382] {aka CMR1, LTRPC6, LTrpC-6, TRPP8, Trp-p8}, SCN9A (sodium voltage-gated channel alpha subunit 9) [NCBI Gene 6335] {aka ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA}, HTR3A (5-hydroxytryptamine receptor 3A) [NCBI Gene 3359] {aka 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3}, KCNH2 (potassium voltage-gated channel subfamily H member 2) [NCBI Gene 3757] {aka ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1}, KCNA6 (potassium voltage-gated channel subfamily A member 6) [NCBI Gene 3742] {aka HBK2, KV1.6, PPP1R96}, Trpv1 (transient receptor potential cation channel, subfamily V, member 1) [NCBI Gene 193034] {aka OTRPC1, TRPV1alpha, TRPV1beta, VR-1, Vr1}, Trpv4 (transient receptor potential cation channel, subfamily V, member 4) [NCBI Gene 63873] {aka 0610033B08Rik, OTRPC4, Trp12, VR-OAC, VRL-2, VROAC}, Trpc1 (transient receptor potential cation channel, subfamily C, member 1) [NCBI Gene 22063] {aka Mtrp1, Trp1, Trrp1}, Trpm1 (transient receptor potential cation channel, subfamily M, member 1) [NCBI Gene 17364] {aka 4732499L03Rik, Ltrpc1, Mlsn1, rd15}, Trpa1 (transient receptor potential cation channel, subfamily A, member 1) [NCBI Gene 312896] {aka Anktm1, rTRPA1}, Trpm5 (transient receptor potential cation channel, subfamily M, member 5) [NCBI Gene 56843] {aka 9430099A16Rik, LTrpC-5, Ltrpc5, Mtr1}, KCNG3 (potassium voltage-gated channel modifier subfamily G member 3) [NCBI Gene 170850] {aka KV10.1, KV6.3}, Trpv3 (transient receptor potential cation channel, subfamily V, member 3) [NCBI Gene 246788] {aka 1110036I10Rik, Nh, VRL3}, HVCN1 (hydrogen voltage gated channel 1) [NCBI Gene 84329] {aka HV1, VSOP}, Trpc6 (transient receptor potential cation channel, subfamily C, member 6) [NCBI Gene 22068] {aka LLHWJM002, LLHWJM003, LLHWJM004, TRP-6, Trrp6, mtrp6}, CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit) [NCBI Gene 1137] {aka BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4}, Trpc3 (transient receptor potential cation channel, subfamily C, member 3) [NCBI Gene 22065] {aka Mwk, Trcp3, Trp3, Trrp3}, Trpv2 (transient receptor potential cation channel, subfamily V, member 2) [NCBI Gene 22368] {aka GRC, OTRPC2, VRL-1, Vrl1}
- **Diseases:** asthma (MESH:D001249), cytotoxic (MESH:D064420), diabetes (MESH:D003920), cancer (MESH:D009369), agitation (MESH:D011595), neurotoxicity (MESH:D020258), tremors (MESH:D014202), skin lesion (MESH:D012871), hypertension (MESH:D006973), pain (MESH:D010146), epilepsy (MESH:D004827), hallucinations (MESH:D006212), injury to (MESH:D014947), inflammatory (MESH:D007249), status epilepticus (MESH:D013226), inherited erythromelalgia (MESH:D004916), absence seizures (MESH:D004832), Seizure (MESH:D012640), epileptiform discharges (MESH:D019522), paroxysmal extreme pain disorder (MESH:C563475), chronic pain (MESH:D059350), neurological diseases (MESH:D020271), depression (MESH:D003866)
- **Chemicals:** nitrogen (MESH:D009584), Na (MESH:D012964), disulfide (MESH:D004220), proton (MESH:D011522), K (MESH:D011188), lidocaine (MESH:D008012), Ca2+ (-), Ca (MESH:D002118), DAG (MESH:D004075), Alkaloid (MESH:D000470), H+ (MESH:D006859), beta-carboline (MESH:C010262), piperazine (MESH:D000077489), thiazole (MESH:D013844), ANE (MESH:C006578), Harmaline (MESH:D006246), fluorine (MESH:D005461), morpholine (MESH:C037574), piperidine (MESH:C032727), Water (MESH:D014867), azobenzene (MESH:C009850)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090], Rattus norvegicus (brown rat, species) [taxon 10116], Conus spurius (species) [taxon 192919], Peganum harmala (species) [taxon 43879]
- **Cell lines:** DF2 — Homo sapiens (Human), Hybrid cell line (CVCL_2437), CHO — Cricetulus griseus (Chinese hamster), Spontaneously immortalized cell line (CVCL_0213)

## Full text

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## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12785892/full.md

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Source: https://tomesphere.com/paper/PMC12785892