# Neuroimmune Regulation by TRPM2 Channels

## TL;DR

TRPM2 channels in the nervous and immune systems play a key role in regulating processes like inflammation, pain, and disease, making them important for developing new treatments.

## Contribution

This paper highlights TRPM2 channels as a critical interface linking the nervous and immune systems, influencing multiple diseases.

## Key findings

- TRPM2 channels in immune cells act as oxidative stress and metabolic sensors involved in innate immunity and inflammation.
- TRPM2 channels in neurons function as oxidative, temperature, and pain sensors, impacting neuronal death and chronic pain.
- TRPM2 channels are linked to diseases like stroke, neurodegeneration, and pain, suggesting their role in therapeutic strategies.

## Abstract

Mutual interaction between the nervous and immune systems underpins many pathophysiological processes. Transient Receptor Potential Melastatin 2 (TRPM2) channels are abundantly expressed in both systems, acting as a critical interface of neuroimmune interaction. TRPM2 channels in immune cells participate in innate immunity and immune inflammation by acting as an oxidative stress and metabolic sensor. TRPM2 in neurons functions not only as an oxidative sensor but also a temperature sensor and a pain transducer critical to neuronal death, temperature sensing, thermoregulation, and chronic pain. Cooperation between immune and neuronal TRPM2 influences the outcome of neuroimmune interaction and many diseases such as infection, inflammation, ischemic stroke, pain, and neurodegenerative diseases. Improved understanding of neuronal and immune TRPM2 interaction is essential for therapeutic interventions for the treatment of diseases mediated by TRPM2 channels.