# XPO5 Polymorphism in Colon Cancer Patients: A Cross-Sectional Study

## TL;DR

This study investigates the XPO5 gene polymorphism in colon cancer patients and finds no significant association with cancer risk.

## Contribution

The study explores the XPO5 rs11544382 polymorphism in colon cancer for the first time in a cross-sectional design.

## Key findings

- No significant association was found between XPO5 rs11544382 genotypes and colon cancer risk.
- Smoking and alcohol consumption were significantly associated with colon cancer.
- AG genotype was the most common in both patients and controls.

## Abstract

(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls) using real-time PCR (qPCR). Logistic regression and Chi-square (χ2) tests were used for statistical analysis. (3) Evaluation of the XPO5 gene polymorphism in CC and control groups revealed no statistically significant association between the mutant (GG) genotype and either the wild-type (AA) or heterozygous (AG) genotypes (χ2 = 2.07, p = 0.151). The AG genotype was predominant in both patients (86.7%) and controls (91.7%). Smoking and alcohol consumption showed significant associations with CC (p < 0.05). Although the rs11544382 polymorphism was not associated with CC risk, this is a cross-sectional study. In light of these findings, larger and more comprehensive studies with increased sample size are required to clarify the relationship between the XPO5 gene polymorphism (rs11544382) and CC.